DBI - diazepam binding inhibitor, acyl-CoA binding protein Gene

Also Known as EP; ACBP; ACBD1; CCK-RP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1622

About DBI

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:119,366,977-119,372,543 (from NCBI)

This gene has 11 transcripts (splice variants), 278 orthologues and 4 paralogues. Ubiquitous expression in prostate (RPKM 97.8), liver (RPKM 93.2) and 25 other tissues.

Summary

This gene encodes diazepam binding inhibitor, a protein that is regulated by Hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

DBI Products (12)

mRNA	Protein	Name
NM_001079862.4	NP_001073331.1	acyl-CoA-binding protein isoform 3
NM_001079863.3	NP_001073332.1	acyl-CoA-binding protein isoform 2
NM_001178017.3	NP_001171488.1	acyl-CoA-binding protein isoform 4
NM_001178041.4	NP_001171512.1	acyl-CoA-binding protein isoform 5
NM_001178042.4	NP_001171513.1	acyl-CoA-binding protein isoform 1
NM_001178043.4	NP_001171514.1	acyl-CoA-binding protein isoform 6
NM_001282633.3	NP_001269562.1	acyl-CoA-binding protein isoform 1
NM_001282634.3	NP_001269563.1	acyl-CoA-binding protein isoform 1
NM_001282635.3	NP_001269564.1	acyl-CoA-binding protein isoform 1
NM_001282636.3	NP_001269565.1	acyl-CoA-binding protein isoform 7
NM_001352432.3	NP_001339361.1	acyl-CoA-binding protein isoform 7
NM_020548.9	NP_065438.1	acyl-CoA-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21079819	GOA
enables long-chain fatty acyl-CoA binding	IDA IDA: Inferred from direct assay	21079819	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of protein lipidation	IDA IDA: Inferred from direct assay	21079819	GOA
involved in phosphatidylcholine acyl-chain remodeling	IDA IDA: Inferred from direct assay	21079819	GOA
involved in positive regulation of CoA-transferase activity	IDA IDA: Inferred from direct assay	21079819	GOA
involved in positive regulation of phospholipid transport	IDA IDA: Inferred from direct assay	21079819	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17953517	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17953517	GOA
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	21698759	GOA
part of protein-lipid complex	IDA IDA: Inferred from direct assay	21079819	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBI Protein Structure

ACBP

0
87 a.a.

Protein Preferred Names	Protein Names
acyl-CoA-binding protein	GABA receptor modulator

Recombinant DBI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72166	DBI Protein, Human (His)	P07108-2 (W2-I104)	≥ 95%, as determined by reducing SDS-PAGE.

DBI Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811061	DBI Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Schizophrenia 14	Sczd14 Schizophrenia, Susceptibility To, 14 Schizophrenia Susceptibility Locus, Chromosome 2q32-Related
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101060	FGIN-1-43		98.96%	Unkown
HY-RS15177	TSPO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162516	DBI-2		/	Unkown
HY-RS03547	DBI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17015	Dbi Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23458	Dbi Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DBI	MGD	MGI:94865
Macaca mulatta	DBI	VGNC	VGNC:71741
Canis familiaris	DBI	VGNC	VGNC:39782
Bos taurus	DBI	VGNC	VGNC:27889
Rattus norvegicus	DBI	RGD	RGD:2490
Others	DBI	NCBI