AGPAT5 - 1-acylglycerol-3-phosphate O-acyltransferase 5 Gene

Also Known as LPAATE; LPLAT5; 1AGPAT5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55326

About AGPAT5

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:6,708,642-6,761,503 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 211 orthologues and 4 paralogues. Broad expression in testis (RPKM 16.0), brain (RPKM 13.8) and 23 other tissues.

Summary

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]

AGPAT5 Products (1)

mRNA Protein Name
NM_018361.5 NP_060831.2 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
21173190 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21173190 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
21173190 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
21173190 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGPAT5 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (82 - 232)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

  • 1-AGP acyltransferase 5

AGPAT5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AGPAT5 Q9NUQ2 CYB561A3 Homo sapiens Q8NBI2
Y2H Array
32296183
Intra
AGPAT5 Q9NUQ2 CYB561A3 Homo sapiens Q8NBI2
Y2H Prey Pooling
32296183
Intra
AGPAT5 Q9NUQ2 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
AGPAT5 Q9NUQ2 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
AGPAT5 Q9NUQ2 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
AGPAT5 Q9NUQ2 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
AGPAT5 Q9NUQ2 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
AGPAT5 Q9NUQ2 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
AGPAT5 Q9NUQ2 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
AGPAT5 Q9NUQ2 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
AGPAT5 Q9NUQ2 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
AGPAT5 Q9NUQ2 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
AGPAT5 Q9NUQ2 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fetal Akinesia Deformation Sequence 4

  • FADS4

  • Fetal Akinesia Deformation Sequence Syndrome 4

  • Akinesia, Fetal, Deformation Sequence, Type 4
Fetal Akinesia Deformation Sequence 1

  • Fetal Akinesia Deformation Sequence

  • Fads

  • Fetal Akinesia Sequence

  • FADS1

  • Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome Type 1

  • Fetal Akinesia Deformation Sequence Syndrome

  • Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

  • Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome, Type I

  • Foetal Akinesia Deformation Sequence Syndrome

  • Foetal Akinesia Sequence

  • Fetal Akinesia Deformation Sequence Syndrome 1

  • Pena-Shokeir Syndrome, Type 1

  • Pena Shokeir Syndrome, Type 1

  • Akinesia, Fetal, Deformation Sequence

  • Akinesia, Fetal, Deformation Sequence, Type 1

  • Pena-Shokeir Syndrome Type I
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00460 AGPAT5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AGPAT5 RGD RGD:1306405
Canis familiaris AGPAT5 VGNC VGNC:49767
Bos taurus AGPAT5 VGNC VGNC:25738
Felis catus AGPAT5 VGNC VGNC:59688
Macaca mulatta AGPAT5 VGNC VGNC:69655
Mus musculus AGPAT5 MGD MGI:1196345
Others AGPAT5 NCBI