MM-02-08
MM-02-08 is a BRD4 PROTAC degrader with a DC50 of approximately 10 nM. MM-02-08 mediates mono-ubiquitination and poly-ubiquitination modifications of target proteins without impairing cell viability. MM-02-08 is applicable to related research on triple-negative breast cancer, prostate cancer, and other diseases.
(Pink: BRD4 ligand (HY-78695); Blue: DDB1 ligand (HY-175890); Black: linker (HY-W004710)).
For research use only. We do not sell to patients.
- Formula: C49H48Cl2N8O4S
- Molecular Weight:915.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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BRD4 10 nM (DC50) |
MM-02-08 (24 h) simultaneously degrades both the short and long isoforms of BRD4 in MDA-MB-231 cells, and this degradation process depends on the functions of the proteasome, ubiquitin-like modification, and DDB1[1].
MM-02-08 selectively degrades the short isoform of BRD4 in HEK293T cells via a proteasome-, NEDDylation- and DDB1-dependent mechanism[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 915.93
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Formula C49H48Cl2N8O4S
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SMILES
O=C(NCCCCCNC(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)=O)C5=CC=C(C6CC(C7=CC(OCC8=CC=CC=C8)=CC=C7)=NN6C(CCl)=O)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MM-02-08 Related Classifications
HY-161167 Related Classifications
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