Correction of changes in ADP-induced platelet aggregation with vasopressin analogue desglycinamide-arginine-vasopressin

  • Bull Exp Biol Med. 2005 Aug;140(2):162-4. doi: 10.1007/s10517-005-0434-8.
M G Golubeva  1 ,  M E Grigoreva ,  M P Smirnova
Affiliations
  • 1. Department of Human and Animals Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. [email protected]
PMID: 16282990 DOI: 10.1007/s10517-005-0434-8
Abstract

We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produced a hemostatic effect and normalized some parameters of blood coagulation.

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