EPO mimetic peptide-1
EPO mimetic peptide-1 (EMP-1), a 20 amino acid peptide. EPO mimetic peptide-1 stimulates cell proliferation, affects cell cycle and induces the production of reticulocytes in vivo.
For research use only. We do not sell to patients.
- CAS No.: 180088-82-8
- Formula: C94H134N26O25S2
- Molecular Weight:2092.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
EPO mimetic peptide-1 shows inhibition of tracer 125I-labeled EPO binding with an IC50 value of 0.2 μM[1]. EPO mimetic peptide-1 (0-50 mM; 48 h) stimulates proliferation of both TF-1 and B6Sut cells in a dose-dependent manner[1]. EPO mimetic peptide-1 (1 and 10 μM) promots erythroid colony formation from human peripheral blood and murine bone marrow[1]. EPO mimetic peptide-1 (10 μM; 10 min) induces the phosphorylation of proteins[1]. EPO mimetic peptide-1 (1 and 10 μM; 0-18 h) affects cell cycle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FDCP-l/mEPOR cell line
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Concentration:10 μM
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Incubation Time:10 min
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Result:Induced the phosphorylation of proteins with apparent molecular weights of 140, 95, 70, and 55 Kd.
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Cell Line:FDCP-l/mEPOR cell line
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Concentration:10 μM
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Incubation Time:0, 6, 8, 10, 12 and 18 h
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Result:Increased cell progression into S phase.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 180088-82-8
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Molecular Weight 2092.36
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Formula C94H134N26O25S2
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Synonyms
EMP-1
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Sequence
Gly-Gly-Thr-Tyr-Ser-Cys-His-Phe-Gly-Pro-Leu-Thr-Trp-Val-Cys-Lys-Pro-Gln-Gly-Gly-NH2 (disulfide bridge:Cys6-Cys15)
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Sequence Shortening
GGTYSCHFGPLTWVCKPQGG-NH2 (disulfide bridge:Cys6-Cys15)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (11.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4779 mL | 2.3896 mL | 4.7793 mL | 11.9482 mL |
| 5 mM | 0.0956 mL | 0.4779 mL | 0.9559 mL | 2.3896 mL | |
| 10 mM | 0.0478 mL | 0.2390 mL | 0.4779 mL | 1.1948 mL |
EPO mimetic peptide-1 Related Classifications
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