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Cat. No.: HY-P3756

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EPO mimetic peptide-1

(Synonyms: EMP-1)

EPO mimetic peptide-1 (EMP-1), a 20 amino acid peptide. EPO mimetic peptide-1 stimulates cell proliferation, affects cell cycle and induces the production of reticulocytes in vivo.

For research use only. We do not sell to patients.

CAS No.: 180088-82-8
Formula: C₉₄H₁₃₄N₂₆O₂₅S₂
Molecular Weight:2092.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EPO mimetic peptide-1 Chemical Structure

CAS No.: 180088-82-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EPO mimetic peptide-1 (EMP-1), a 20 amino acid peptide. EPO mimetic peptide-1 stimulates cell proliferation, affects cell cycle and induces the production of reticulocytes in vivo^[1].

In Vitro

EPO mimetic peptide-1 shows inhibition of tracer ¹²⁵I-labeled EPO binding with an IC₅₀ value of 0.2 μM^[1].
EPO mimetic peptide-1 (0-50 mM; 48 h) stimulates proliferation of both TF-1 and B6Sut cells in a dose-dependent manner^[1].
EPO mimetic peptide-1 (1 and 10 μM) promots erythroid colony formation from human peripheral blood and murine bone marrow^[1].
EPO mimetic peptide-1 (10 μM; 10 min) induces the phosphorylation of proteins^[1].
EPO mimetic peptide-1 (1 and 10 μM; 0-18 h) affects cell cycle^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

FDCP-l/mEPOR cell line
Concentration:

10 μM
Incubation Time:

10 min
Result:

Induced the phosphorylation of proteins with apparent molecular weights of 140, 95, 70, and 55 Kd.

Cell Cycle Analysis^[1]

Cell Line:

FDCP-l/mEPOR cell line
Concentration:

10 μM
Incubation Time:

0, 6, 8, 10, 12 and 18 h
Result:

Increased cell progression into S phase.

In Vivo

EPO mimetic peptide-1 (1-2 mg; once) induces the production of reticulocytes over the background of endogenous in normal, untreated mice containing endogenous basal levels of EPO mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 180088-82-8
Molecular Weight 2092.36
Formula C₉₄H₁₃₄N₂₆O₂₅S₂
Synonyms

EMP-1
Sequence

Gly-Gly-Thr-Tyr-Ser-Cys-His-Phe-Gly-Pro-Leu-Thr-Trp-Val-Cys-Lys-Pro-Gln-Gly-Gly-NH2 (disulfide bridge:Cys6-Cys15)
Sequence Shortening

GGTYSCHFGPLTWVCKPQGG-NH2 (disulfide bridge:Cys6-Cys15)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wrighton NC, et al. Small peptides as potent mimetics of the protein hormone erythropoietin. Science. 1996 Jul 26;273(5274):458-64. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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