NFATC3 - nuclear factor of activated T cells 3 Gene

Also Known as NFAT4; NFATX; NF-AT4c; n339260

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4775

About NFATC3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,085,370-68,229,259 (from NCBI)

This gene has 22 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 17.4), lymph node (RPKM 16.5) and 25 other tissues.

Summary

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

NFATC3 Products (3)

mRNA Protein Name
NM_004555.4 NP_004546.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
NM_173163.3 NP_775186.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform 3
NM_173165.3 NP_775188.1 nuclear factor of activated T-cells, cytoplasmic 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15173172 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
15173172 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
23543060 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15173172 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24330068 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of miRNA transcription IGI
IGI: Inferred from genetic interaction
23543060 GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
23853098 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18815128 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15173172 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18815128 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12370307 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFATC3 Protein Structure

RHD_DNA_bind

RHD_DNA_bind: Rel homology DNA-binding domain (433 - 592)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1075 a.a.
Protein Preferred Names Protein Names

nuclear factor of activated T-cells, cytoplasmic 3

  • NF-ATc3

NFATC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NFATC3 Q12968 RAF1 Homo sapiens P04049
Anti Bait CoIP
24330068
Intra
NFATC3 Q12968 SUFU Homo sapiens Q9UMX1
Anti Tag CoIP
33961781
Intra
NFATC3 Q12968 SUFU Homo sapiens Q9UMX1
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukostasis
Polyomavirus-Associated Nephropathy

  • Polyomavirus Associated Nephropathy

  • Pvan
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1353 Rhamnocitrin Inhibitor 99.67% Unkown
HY-P10889 CNI103 Inhibitor 99.56% Unkown
HY-RS09241 NFATC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NFATC3 VGNC VGNC:43769
Macaca mulatta NFATC3 VGNC VGNC:75328
Bos taurus NFATC3 VGNC VGNC:32033
Felis catus NFATC3 VGNC VGNC:68471
Rattus norvegicus NFATC3 RGD RGD:1308692
Mus musculus NFATC3 MGD MGI:103296
Others NFATC3 NCBI