Norepinephrine tartrate
Based on 74 publication(s) in Google Scholar
Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α1, α2, β1 receptors.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.96%
- No. CAS: 51-40-1
- Fòrmula: C12H17NO9
- Peso molecular:319.26
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Almacenamiento:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Publications Citing Use of MedChemExpress (MCE) Norepinephrine tartrate
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]
- Cell. 2025 Sep 18;188(19):5142-5156.e23. [Abstract]
- Immunity. 2026 Mar 10;59(3):598-617.e11. [Abstract]
- Cell Mol Immunol. 2023 Feb;20(2):175-188. [Abstract]
- Cell Stem Cell. 2025 Mar 20:S1934-5909(25)00084-0. [Abstract]
- Nat Commun. 2025 Jun 5;16(1):5215. [Abstract]
- Nat Commun. 2024 May 7;15(1):3834. [Abstract]
- Nat Commun. 2022 Jul 25;13(1):4278. [Abstract]
- ACS Nano. 2022 Aug 23;16(8):12553-12568. [Abstract]
- Cell Discov. 2025 May 13;11(1):46. [Abstract]
- Theranostics. 2026 Jan 1;16(7):3263-3285. [Abstract]
- Theranostics. 2022 Jun 6;12(10):4718-4733. [Abstract]
- Adv Sci (Weinh). 2026 Jun 13:e23067. [Abstract]
- MedComm (2020). 2026 Mar 28;7(4):e70706. [Abstract]
- Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]
- Cell Rep Med. 2023 Jun 20;4(6):101061. [Abstract]
- Sci Adv. 2026 Mar 6;12(10):eaea7017. [Abstract]
- Cardiovasc Res. 2018 Feb 1;114(2):300-311. [Abstract]
- Cell Death Dis. 2020 Aug 18;11(8):644. [Abstract]
- Cell Commun Signal. 2024 Jul 25;22(1):375. [Abstract]
- J Neuroinflammation. 2026 Jun 16. [Abstract]
- Mater Today Bio. 2026 May 2:38:103197. [Abstract]
- Mater Today Bio. 2025 Oct 2:35:102364. [Abstract]
- Acta Pharmacol Sin. 2026 May 27. [Abstract]
- Acta Pharmacol Sin. 2026 May 29. [Abstract]
- Basic Res Cardiol. 2025 Mar 23. [Abstract]
- Chin Med J (Engl). 2026 Apr 23. [Abstract]
- Cell Rep. 2019 Dec 3;29(10):2936-2943.e4. [Abstract]
- Transl Psychiatry. 2025 May 17;15(1):172. [Abstract]
- Br J Pharmacol. 2020 Aug;177(15):3389-3402. [Abstract]
- Anal Chem. 2026 Jun 16;98(23):16962-16970. [Abstract]
- Anal Chem. 2025 Jul 15;97(27):14220-14229. [Abstract]
- Food Science and Human Wellness. 2023 Nov;12(6);2061-2072.
- Redox Rep. 2025 Dec;30(1):2494314. [Abstract]
- J Ethnopharmacol. 2025 Jan 30;337(Pt 2):118860. [Abstract]
- ACS Biomater Sci Eng. 2026 Feb 19. [Abstract]
- J Am Heart Assoc. 2019 Jan 8;8(1):e009871. [Abstract]
- Eur J Pharmacol. 2026 Jul 10:1029:178996. [Abstract]
- Mar Drugs. 2026 Jun;24(6):189. [Abstract]
- Eur J Pharmacol. 2022 Jul 15:927:175022. [Abstract]
- Int J Mol Sci. 2026 Apr 9;27(8):3381. [Abstract]
- Int J Mol Sci. 2025 Mar 2;26(5):2243. [Abstract]
- Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):13. [Abstract]
- Neurochem Int. 2021 Feb:143:104942. [Abstract]
- J Nutr Biochem. 2018 Aug:58:110-118. [Abstract]
- J Mol Med (Berl). 2026 Mar 19;104(1):53. [Abstract]
- Sci Rep. 2022 Jun 15;12(1):9936. [Abstract]
- J Physiol. 2025 Oct 9. [Abstract]
- iScience. 2026 Feb 28;29(4):115189. [Abstract]
- iScience. 2026 Feb 23;29(3):115122. [Abstract]
- FASEB J. 2020 Nov;34(11):14892-14904. [Abstract]
- J Biol Chem. 2024 Dec;300(12):107924. [Abstract]
- Am J Physiol Renal Physiol. 2024 Nov 1;327(5):F885-F898. [Abstract]
- Exp Cell Res. 2026 Jun 9;461(1):115102. [Abstract]
- Cell Biochem Funct. 2024 Jan;42(1):e3915. [Abstract]
- Mol Cell Endocrinol. 2025 Jan 15:596:112417. [Abstract]
- J Cancer. 2024 Sep 9;15(17):5691-5709. [Abstract]
- Neuroscience. 2019 Mar 1:401:59-72. [Abstract]
- J Therm Biol. 2024 Jul:123:103906. [Abstract]
- Cell Tissue Res. 2026 Jun 24;405(1):3. [Abstract]
- Fitoterapia. 2026 Apr:190:107182. [Abstract]
- Gene. 2023 Dec 20:888:147753. [Abstract]
- Biochem Biophys Res Commun. 2023 May 21:657:108-118. [Abstract]
- J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15:1092:220-227. [Abstract]
- Ocul Immunol Inflamm. 2025 Jul;33(5):766-780. [Abstract]
- Turk J Med Sci. 2025 Feb 19;55(2):509-517. [Abstract]
- bioRxiv. 2025 Oct 2.
- bioRxiv. 2024 November 03.
- bioRxiv. 2024 July 31.
- bioRxiv. 2023 Oct 13.
- SSRN. 2023 May 8.
- Leiden University. 2022.
- Research Square Preprint. 2021 Aug.
Customer Validation & Images
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WB
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Cell Imaging/Staining
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RT-PCR
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Cell Imaging/Staining
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RT-PCR
Ver todos los productos específicos de isoformas Endogenous Metabolite
MoreVer todos los productos específicos de isoformas Adrenergic Receptor
More
Actividad biológica
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α1-adrenergic receptor |
α2-adrenergic receptor |
Beta-1 adrenergic receptor |
Microbial Metabolite |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
1019 nM
Compound: noradrenaline
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Agonist activity at human alpha1L-adrenoceptor expressed in CHO cells co-expressing CRELD1alpha assessed as induction of calcium mobilization after 60 mins by fluorometric imaging plate reader assay
Agonist activity at human alpha1L-adrenoceptor expressed in CHO cells co-expressing CRELD1alpha assessed as induction of calcium mobilization after 60 mins by fluorometric imaging plate reader assay
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[PMID: 26087939] |
Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β2-adrenoceptor in higher concentrations[2]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effectNorepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Subcutaneous preadipocytes Adipocytes.
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Concentration:10 μM.
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Incubation Time:6 hours.
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Result:AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA)
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 51-40-1
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Appearance Solid
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Peso molecular 319.26
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Fòrmula C12H17NO9
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Color White to off-white
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SMILES
OC1=CC=C([C@@H](O)CN)C=C1O.OC([C@H](O)[C@@H](O)C(O)=O)=O
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Synonyms
Levarterenol tartrate; L-Noradrenaline tartrate
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (74)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin. [Abstract]2026 Mar 5;189(5):1323-1340.e25. PMID: 41616781
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]
Norepinephrine bitartrate monohydrate (NE) (0.5 mM; 12 h) decreased CXCL16 level in mouse and human cultured keratinocytes.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]
Norepinephrine bitartrate monohydrate (NE) (2 mM; 100 μL; i.d.) caused a pronounced decrease in keratinocyte CXCL16 expression in C57BL/6J mice.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]
Norepinephrine bitartrate monohydrate (NE) (0.5 mM; 12 h) decreased Cxcl16 and Tgfb3 expression in cultured mouse keratinocytes.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]
Norepinephrine bitartrate monohydrate (NE) (2 mM; 100 μL; i.d.) led to a significant reduction of skin CD8+ TRM cells in C57BL/6J mice.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]
Norepinephrine bitartrate monohydrate (NE) (0.5 mM; 12 h) decreased Cxcl16 and Tgfb3 expression in cultured human keratinocytes.
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Cell
2025 Sep 18;188(19):5142-5156.e23. PMID: 40555230 -
Immunity
2026 Mar 10;59(3):598-617.e11. PMID: 41722568 -
Cell Mol Immunol
β-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response. [Abstract]2023 Feb;20(2):175-188. PMID: 36600052
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Feb;20(2):175-188. [Abstract]
Effects of epinephrine (EPI) and norepinephrine (NE) on virus-induced transcription of antiviral genes. THP1 cells (1 × 106) were treated with EPI or NE (10 μM) and then uninfected or infected with SeV or HSV-1 (MOI = 1), and at the indicated times, qPCR analysis was performed to determine the levels of the indicated mRNAs.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Feb;20(2):175-188. [Abstract]
Effects of EPI/NE/isoprenaline (ISO) on virus-induced transcription of antiviral genes. THP1 cells (1 × 106) were treated with EPI, NE or ISO (10 μM) and uninfected or infected with EMCV (MOI = 1). Ten hours later, qPCR analysis was performed to determine the levels of the indicated mRNAs.
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Cell Stem Cell
Vagal pathway activation links chronic stress to decline in intestinal stem cell function. [Abstract]2025 Mar 20:S1934-5909(25)00084-0. PMID: 40120585 -
Nat Commun
A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway. [Abstract]2025 Jun 5;16(1):5215. PMID: 40473608 -
Nat Commun
Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes. [Abstract]2024 May 7;15(1):3834. PMID: 38714741
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 May 7;15(1):3834. [Abstract]
Representative images of DLAT oligomer immunofluorescence imaging by confocal microscopy. Scale bar = 20 μm. HL-1 cells were treated with 10 µM CuCl2 in the presence of solvent (DMSO), 1 µM NE or 10 µM NE for 24 h.
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Nat Commun
The RalGAPα1-RalA signal module protects cardiac function through regulating calcium homeostasis. [Abstract]2022 Jul 25;13(1):4278. PMID: 35879328 -
ACS Nano
Nanoparticle-Driven Controllable Mitochondrial Regulation through Lysosome-Mitochondria Interactome. [Abstract]2022 Aug 23;16(8):12553-12568. PMID: 35876466 -
Cell Discov
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis. [Abstract]2025 May 13;11(1):46. PMID: 40360481 -
Theranostics
Hilnc- mediated UCP1 translation repression contributes to thermogenesis and energy expenditure. [Abstract]2026 Jan 1;16(7):3263-3285. PMID: 41608567 -
Theranostics
Norepinephrine acting on adventitial fibroblasts stimulates vascular smooth muscle cell proliferation via promoting small extracellular vesicle release. [Abstract]2022 Jun 6;12(10):4718-4733. PMID: 35832088 -
Adv Sci (Weinh)
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis. [Abstract]2026 Jun 13:e23067. PMID: 42287124 -
MedComm (2020)
2026 Mar 28;7(4):e70706. PMID: 41930327 -
Adv Sci (Weinh)
Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress-Related Male Reproductive Dysfunction. [Abstract]2025 Oct 6:e04817. PMID: 41051274
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]
Atenolol (ATN, 1 µM, 72 h) rescued the Norepinephrine (NE, 10 µM)-induced decrease in TM4 cell viability.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]
Atenolol (ATN, 1 µM, 48 h) restored the Norepinephrine (NE, 10 µM)-induced increase in intracellular ferrous ion concentration in TM4 cells.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]
Atenolol (ATN, 1 µM, 48 h) restored the Norepinephrine (NE, 10 µM)-induced decrease in mitochondrial membrane potential in TM4 cells.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]
Atenolol (ATN, 1 µM, 48 h) reversed Norepinephrine (NE,10 μM）-induced alterations in the expression of SLC7A11, GPX4, and ACSL4 in TM4 cells.
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]
Atenolol (ATN, 1 µM, 48 h) reversed Norepinephrine (NE,10 μM）-induced alterations in the expression of SLC7A11, GPX4, and ACSL4 in TM4 cells.
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Cell Rep Med
2023 Jun 20;4(6):101061. PMID: 37267943 -
Sci Adv
Sympathetic nerve aggravates autoimmune skin disease via NE-adrenergic receptor axis: Neuroimmune cross-talk insights from vitiligo. [Abstract]2026 Mar 6;12(10):eaea7017. PMID: 41779853 -
Cardiovasc Res
2018 Feb 1;114(2):300-311. PMID: 29155983
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311. [Abstract]
Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).
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Cell Death Dis
Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis. [Abstract]2020 Aug 18;11(8):644. PMID: 32811805 -
Cell Commun Signal
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress. [Abstract]2024 Jul 25;22(1):375. PMID: 39054537 -
J Neuroinflammation
2026 Jun 16. PMID: 42298686 -
Mater Today Bio
Mucoadhesive oral nanovaccine delivery system with immunomodulatory capacity for synergistic colorectal cancer therapy. [Abstract]2026 May 2:38:103197. PMID: 42170236 -
Mater Today Bio
2025 Oct 2:35:102364. PMID: 41127547 -
Acta Pharmacol Sin
Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility. [Abstract]2026 May 27. PMID: 42191898 -
Acta Pharmacol Sin
Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation. [Abstract]2026 May 29. PMID: 42215618 -
Basic Res Cardiol
Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion. [Abstract]2025 Mar 23. PMID: 40121575 -
Chin Med J (Engl)
Skin-localized sympathetic nerve-keratinocyte crosstalk fuels psoriatic inflammation via neutrophil recruitment. [Abstract]2026 Apr 23. PMID: 42036893 -
Cell Rep
Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor. [Abstract]2019 Dec 3;29(10):2936-2943.e4. PMID: 31801061 -
Transl Psychiatry
Stellate ganglion block diminishes consolidation of conditioned fear memory in mice by inhibiting the locus coeruleus to the basolateral amygdala neural circuit. [Abstract]2025 May 17;15(1):172. PMID: 40382311 -
Br J Pharmacol
Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury. [Abstract]2020 Aug;177(15):3389-3402. PMID: 32232832 -
Anal Chem
High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules. [Abstract]2026 Jun 16;98(23):16962-16970. PMID: 42223360 -
Anal Chem
2025 Jul 15;97(27):14220-14229. PMID: 40601392 -
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Redox Rep
Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation. [Abstract]2025 Dec;30(1):2494314. PMID: 40269356 -
J Ethnopharmacol
Mechanistic insights into Suanzaoren Decoction's improvement of cardiac contractile function in anxiety-induced cardiac insufficiency. [Abstract]2025 Jan 30;337(Pt 2):118860. PMID: 39341264 -
ACS Biomater Sci Eng
Catecholamine-Derived Surface Chemistry Regulates Cell-Type-Specific Adhesion and Migration in Uterine Cells. [Abstract]2026 Feb 19. PMID: 41715268 -
J Am Heart Assoc
New Molecular Mechanism Underlying Myc-Mediated Cytochrome P450 2E1 Upregulation in Apoptosis and Energy Metabolism in the Myocardium. [Abstract]2019 Jan 8;8(1):e009871. PMID: 30563421 -
Eur J Pharmacol
Establishment of a novel model of depression caused by olfactory dysfunction through intranasal administration of 3-methylindole. [Abstract]2026 Jul 10:1029:178996. PMID: 42167669 -
Mar Drugs
GV-971 Ameliorates Chronic Restraint Stress-Induced Depression-like Phenotypes Accompanied by Reshaping of the Microbiota-Gut-Brain Axis. [Abstract]2026 Jun;24(6):189. PMID: 42346775 -
Eur J Pharmacol
Phillyrin attenuates norepinephrine-induced cardiac hypertrophy and inflammatory response by suppressing p38/ERK1/2 MAPK and AKT/NF-kappaB pathways. [Abstract]2022 Jul 15:927:175022. PMID: 35569549 -
Int J Mol Sci
A Clozapine-Responsive GPCR-Based Gene Switch for Pharmacological Control of Gene Expression in Mammalian Cells and In Vivo. [Abstract]2026 Apr 9;27(8):3381. PMID: 42074026 -
Int J Mol Sci
Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds. [Abstract]2025 Mar 2;26(5):2243. PMID: 40076865 -
Invest Ophthalmol Vis Sci
Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice. [Abstract]2025 Jun 2;66(6):13. PMID: 40465266 -
Neurochem Int
Astroglial adrenoreceptors modulate synaptic transmission and contextual fear memory formation in dentate gyrus. [Abstract]2021 Feb:143:104942. PMID: 33340594 -
J Nutr Biochem
Genistein rescues hypoxia-induced pulmonary arterial hypertension through estrogen receptor and β-adrenoceptor signaling. [Abstract]2018 Aug:58:110-118. PMID: 29886191
Norepinephrine tartrate purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2018 Aug:58:110-118. [Abstract]
PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.
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J Mol Med (Berl)
Tyrosine hydroxylase as a therapeutic target: insights from adrenergic nerve and TNBC cell interactions. [Abstract]2026 Mar 19;104(1):53. PMID: 41857421 -
Sci Rep
Glutamine and norepinephrine in follicular fluid synergistically enhance the antioxidant capacity of human granulosa cells and the outcome of IVF-ET. [Abstract]2022 Jun 15;12(1):9936. PMID: 35705692 -
J Physiol
2025 Oct 9. PMID: 41066225 -
iScience
Long-term vagus nerve stimulation synergized with rapamycin elicits neuroimmune modulation to prolong skin allograft survival. [Abstract]2026 Feb 28;29(4):115189. PMID: 41858626 -
iScience
2026 Feb 23;29(3):115122. PMID: 41852725 -
FASEB J
Inhibition of α1-adrenoceptor reduces TGF-β1-induced epithelial-to-mesenchymal transition and attenuates UUO-induced renal fibrosis in mice. [Abstract]2020 Nov;34(11):14892-14904. PMID: 32939891 -
J Biol Chem
STIM1 functions as a proton sensor to coordinate cytosolic pH with store-operated calcium entry. [Abstract]2024 Dec;300(12):107924. PMID: 39454952 -
Am J Physiol Renal Physiol
Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats. [Abstract]2024 Nov 1;327(5):F885-F898. PMID: 39298550 -
Exp Cell Res
Molecular mechanism of MAFB transcriptional activation of PPARD in regulating adipose browning and protecting against vascular endothelial cell injury. [Abstract]2026 Jun 9;461(1):115102. PMID: 42264121 -
Cell Biochem Funct
2024 Jan;42(1):e3915. PMID: 38269513 -
Mol Cell Endocrinol
Macrophage NLRP3 inflammasome mediates the effects of sympathetic nerve on cardiac remodeling in obese rats. [Abstract]2025 Jan 15:596:112417. PMID: 39557185 -
J Cancer
Pan-cancer analysis of the role of α2C-adrenergic receptor (ADRA2C) in human tumors and validation in glioblastoma multiforme models. [Abstract]2024 Sep 9;15(17):5691-5709. PMID: 39308687 -
Neuroscience
Natural Killer Cells may Exert Antidepressant-like Effects in Mice by Controlling the Release of Inflammatory Factors. [Abstract]2019 Mar 1:401:59-72. PMID: 30641114 -
J Therm Biol
Differential expression of ADRB1 causes different responses to norepinephrine in adipocytes of Duroc-Landrace-Yorkshire pigs and min pigs. [Abstract]2024 Jul:123:103906. PMID: 38970835 -
Cell Tissue Res
Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling. [Abstract]2026 Jun 24;405(1):3. PMID: 42337146 -
Fitoterapia
The stem-derived bioactive fraction of Syringa oblata Lindl. Ameliorates insomnia via cAMP signaling-mediated regulation of neurotransmission, oxidative stress, and inflammation: A multi-omics study. [Abstract]2026 Apr:190:107182. PMID: 41861857 -
Gene
Transcriptome Analysis of Norepinephrine-induced Lipolysis in Differentiated Adipocytes of Bama Pig. [Abstract]2023 Dec 20:888:147753. PMID: 37659599 -
Biochem Biophys Res Commun
Estrogen ameliorates sepsis-induced vascular hyporeactivity in thoracic aorta of female rats via permissive effect of GRα expression. [Abstract]2023 May 21:657:108-118. PMID: 37002984 -
J Chromatogr B Analyt Technol Biomed Life Sci
Searching for synergistic calcium antagonists and novel therapeutic regimens for coronary heart disease therapy from a Traditional Chinese Medicine, Suxiao Jiuxin Pill. [Abstract]2018 Aug 15:1092:220-227. PMID: 29908471 -
Ocul Immunol Inflamm
Norepinephrine Attenuates Benzalkonium Chloride-Induced Dry Eye Disease by Regulating the PINK1/Parkin Mitophagy Pathway. [Abstract]2025 Jul;33(5):766-780. PMID: 39731302 -
Turk J Med Sci
2025 Feb 19;55(2):509-517. PMID: 40342326 -
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Solvente y solubilidad
DMSO : 100 mg/mL (313.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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-
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (285 KB)
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SDS (481 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Brian P Ramos, et al. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther. 2007 Mar;113(3):523-36. [Content Brief]
[2]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [Content Brief]
[3]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. [Content Brief]
[4]. Xinyu Xu, et al. Binding pathway determines norepinephrine selectivity for the human β 1 AR over β 2 AR. Cell Res. 2021 May;31(5):569-579. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1322 mL | 15.6612 mL | 31.3224 mL | 78.3061 mL |
| 5 mM | 0.6264 mL | 3.1322 mL | 6.2645 mL | 15.6612 mL | |
| 10 mM | 0.3132 mL | 1.5661 mL | 3.1322 mL | 7.8306 mL | |
| 15 mM | 0.2088 mL | 1.0441 mL | 2.0882 mL | 5.2204 mL | |
| 20 mM | 0.1566 mL | 0.7831 mL | 1.5661 mL | 3.9153 mL | |
| 25 mM | 0.1253 mL | 0.6264 mL | 1.2529 mL | 3.1322 mL | |
| 30 mM | 0.1044 mL | 0.5220 mL | 1.0441 mL | 2.6102 mL | |
| 40 mM | 0.0783 mL | 0.3915 mL | 0.7831 mL | 1.9577 mL | |
| 50 mM | 0.0626 mL | 0.3132 mL | 0.6264 mL | 1.5661 mL | |
| 60 mM | 0.0522 mL | 0.2610 mL | 0.5220 mL | 1.3051 mL | |
| 80 mM | 0.0392 mL | 0.1958 mL | 0.3915 mL | 0.9788 mL | |
| 100 mM | 0.0313 mL | 0.1566 mL | 0.3132 mL | 0.7831 mL |
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