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Cat. No.: HY-P5915

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FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2

FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2, a 5-FAM labeled HIF-1α peptide, is a substrate of VHL. FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 binds to VHL protein with a K_D of 3 nM. Ex/Em (λ) = 485/520 nm.

For research use only. We do not sell to patients.

Formula: C₁₂₂H₁₅₈N₂₄O₃₉S
Molecular Weight:2616.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2, a 5-FAM labeled HIF-1α peptide, is a substrate of VHL. FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 binds to VHL protein with a K_D of 3 nM. Ex/Em (λ) = 485/520 nm^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Chemical Information

Molecular Weight 2616.76
Formula C₁₂₂H₁₅₈N₂₄O₃₉S
Sequence

{FAM}-Asp-Glu-Ala-Leu-Ala-{Hyp}-Tyr-Ile-Pro-Met-Asp-Asp-Asp-Phe-Gln-Leu-Arg-Ser-Phe-NH2
Sequence Shortening

{FAM}-DEALA-{Hyp}-YIPMDDDFQLRSF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dennis L Buckley, et al. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction. J Am Chem Soc. 2012 Mar 14;134(10):4465-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2

All HIF/HIF Prolyl-Hydroxylase Isoforms