FWM-1

Cat. No.: HY-144800 Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

FWM-1 is a potent SARS-COV-2 NSP13 helicase enzyme inhibitor with binding free energy equals -328.6 kcal/mol. FWM-1 effectively disrupts the binding of ATP to the SARS-COV2 helicase enzyme.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

FWM-1 화학구조

CAS No. : 219542-52-6

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

FWM-1 is a potent SARS-COV-2 NSP13 helicase enzyme inhibitor with binding free energy equals -328.6 kcal/mol. FWM-1 effectively disrupts the binding of ATP to the SARS-COV2 helicase enzyme^[1].

IC₅₀ & Target

NSP13^[1].

분자량

410.86

화학식

C₁₅H₁₁ClN₄O₄S₂

CAS No.

219542-52-6

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(NC(O)=C1C(C2=C(NC(NC2=O)=S)O)C3=CC=C(C=C3)Cl)=S

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (121.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4339 mL	12.1696 mL	24.3392 mL
5 mM	0.4868 mL	2.4339 mL	4.8678 mL
10 mM	0.2434 mL	1.2170 mL	2.4339 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 95.0%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (256 KB) HNMR (264 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. El Hassab MA, et al. Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):563-572. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4339 mL	12.1696 mL	24.3392 mL	60.8480 mL
	5 mM	0.4868 mL	2.4339 mL	4.8678 mL	12.1696 mL
	10 mM	0.2434 mL	1.2170 mL	2.4339 mL	6.0848 mL
	15 mM	0.1623 mL	0.8113 mL	1.6226 mL	4.0565 mL
	20 mM	0.1217 mL	0.6085 mL	1.2170 mL	3.0424 mL
	25 mM	0.0974 mL	0.4868 mL	0.9736 mL	2.4339 mL
	30 mM	0.0811 mL	0.4057 mL	0.8113 mL	2.0283 mL
	40 mM	0.0608 mL	0.3042 mL	0.6085 mL	1.5212 mL
	50 mM	0.0487 mL	0.2434 mL	0.4868 mL	1.2170 mL
	60 mM	0.0406 mL	0.2028 mL	0.4057 mL	1.0141 mL
	80 mM	0.0304 mL	0.1521 mL	0.3042 mL	0.7606 mL
	100 mM	0.0243 mL	0.1217 mL	0.2434 mL	0.6085 mL

FWM-1 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FWM-1219542-52-6FWM1FWM 1SARS-CoVSARS coronavirusSARS-COV-2structure-based pharmacophoreATPInhibitorinhibitorinhibit

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FWM-1

FWM-1 Related Antibodies

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Biological Activity

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