98106-17-3
Chemical Structure
Difloxacin
Synonym(s): A-56619
- No. CAS: 98106-17-3
- Formula:C21H19F2N3O3
- Molecular Weight:399.39
IUPAC Name: 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChIKey: NOCJXYPHIIZEHN-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(N4CCN(C)CC4)=C3)C1=O)O
Biological Activity: Difloxacin (A-56619) is an orally active bactericidal agent. Difloxacin inhibits bacterial DNA gyrase. Difloxacin exhibits concentration-dependent bactericidal activity. Difloxacin shows strong in vitro activity against a variety of Gram-positive and Gram-negative bacteria. Difloxacin can be used in research related to colibacillosis and Staphylococcus aureus infections[1][2][3].
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Difloxacin | Difloxacin (A-56619) is an orally active bactericidal agent. Difloxacin inhibits bacterial DNA gyrase. Difloxacin exhibits concentration-dependent bactericidal activity. Difloxacin shows strong in vitro activity against a variety of Gram-positive and Gram-negative bacteria. Difloxacin can be used in research related to colibacillosis and Staphylococcus aureus infections. | |||||||||||||||||||||
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Difloxacin-d3 | 98.0% | Difloxacin-d3 is the deuterium labeled Difloxacin. | ||||||||||||||||||||
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Difloxacin-d3 (hydrochloride) | 99.0% | Difloxacin-d3 (hydrochloride) is the deuterium labeled Difloxacin (hydrochloride). | ||||||||||||||||||||
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Difloxacin-d3 hydrochloride trihydrate | Difloxacin-d3 (hydrochloride trihydrate) is a deuterium labeled Difloxacin. Difloxacin is an antimicrobial agent. | |||||||||||||||||||||
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References
- [1]. Abo El-Ela FI, et al. Pharmacokinetics of difloxacin in healthy and E. coli-infected broiler chickens. Br Poult Sci. 2014;55(6):830-836. [Content Brief]
- [2]. Fernandes PB, et al. In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrob Agents Chemother. 1986;29(2):201-208. [Content Brief]
- [3]. Gollapudi SV, et al. Aryl-fluoroquinolone derivatives A-56619 (difloxacin) and A-56620 inhibit mitogen-induced human mononuclear cell proliferation. Antimicrob Agents Chemother. 1986;30(3):390-394. [Content Brief]
