CD73-IN-14
D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8+ cells and shows anti-tumor activity. CD73-IN-14 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- No. CAS: 2407356-67-4
- Fòrmula: C26H26ClN7O9
- Peso molecular:615.98
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
C50: 0.17 nM (CD73)[1]
In Vivo
| PO Dose (mg/kg) | AUC0-24 h (ng*hr/mL) | Cmax(nM) | Tmax(hr) |
| 50 | 580 | 74 | 0.8 |
| 200 | 6094 | 1800 | 0.8 |
| 500 | 18500 | 11000 | 0.3 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (EG7 model)[1]
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Dosage:10, 25, 50 mg/kg
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Administration:P.o.; twice a day for 20 days
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Result:Increased tumor-infiltrating CD8+ cells and decreased the tumor volume in a dose dependet manner.
Chemical Information
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No. CAS 2407356-67-4
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Peso molecular 615.98
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Fòrmula C26H26ClN7O9
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SMILES
ClC1=NC2=C(N=CN2[C@H]3[C@@H]([C@@](C#C)([C@H](O3)COC(CC4=CC=C(C=C4)N5C(NCCC5)=O)(C(O)=O)C(O)=O)O)O)C(N)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CD73-IN-14 Related Classifications
HY-152074 Related Classifications
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