CDK2-IN-57
CDK2-IN-57 is a selective Cdk2/CycE inhibitor with an IC50 of 2.8 nM. CDK2-IN-57 inhibits Cdk1/2 kinase activity, blocks cell cycle progression, induces G0-phase cell cycle arrest, and prevents S-phase entry. CDK2-IN-57 can be used for the research of colon carcinoma.
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- Fòrmula: C22H30N4O4
- Peso molecular:414.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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CDK2/Cyc E 2.8 nM (IC50) |
CDK2-IN-57 (Compound 22) potently inhibits the purified Cdk2/CycE complex with an IC50 of 2.8 nM[1].
CDK2-IN-57 (20 nM-100 μM; 48 h) induces dose-responsive cell cycle arrest at G0 and reduced viability in HCT-116 colon cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 colon cancer cells
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Concentration:20 nM; 50 nM; 100 nM; 200 nM; 390 nM; 780 nM; 1.56 μM; 3.13 μM; 6.25 μM; 12.5 μM; 25 μM; 50 μM; 100 μM
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Incubation Time:48 h
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Result:Reduced cell number of cells positive for Edu and pHH3 in a dose-dependent manner.
Induces dose-responsive cell cycle arrest at G0 and reduced viability.
Chemical Information
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Peso molecular 414.50
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Fòrmula C22H30N4O4
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SMILES
O=C(CC1=CC=C(C=C1)OC)NC2=NNC([C@H]3CC[C@@H](OC(N(C)C(C)C)=O)C3)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK2-IN-57 Related Classifications
HY-183146 Related Classifications
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