EPHA2 - EPH receptor A2 Gene

Also Known as ECK; CTPA; ARCC2; CTPP1; CTRCT6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1969

About EPHA2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,124,337-16,156,069 (from NCBI)

This gene has 4 transcripts (splice variants), 124 orthologues, 53 paralogues and is associated with 6 phenotypes. Broad expression in esophagus (RPKM 37.8), urinary bladder (RPKM 18.3) and 21 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]

EPHA2 Products (2)

mRNA	Protein	Name
NM_001329090.2	NP_001316019.1	ephrin type-A receptor 2 isoform 2
NM_004431.5	NP_004422.2	ephrin type-A receptor 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables growth factor binding	IPI IPI: Inferred from physical interaction	22568954	GOA
enables molecular function activator activity	EXP EXP: Inferred from Experiment	12467573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10655584	GOA
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10655584	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20679435	GOA
involved in cAMP metabolic process	IMP IMP: Inferred from mutant phenotype	27385333	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	19573808	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	23358419	GOA
involved in cell motility	IMP IMP: Inferred from mutant phenotype	26158630	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	10655584	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	18339848	GOA
involved in keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	20861311	GOA
involved in positive regulation of bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	27815408	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	24002999	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	20679435	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	27815408	GOA
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20861311	GOA
involved in regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	10655584	GOA
involved in regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	19573808	GOA
involved in response to growth factor	IMP IMP: Inferred from mutant phenotype	19573808	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in cell surface	IDA IDA: Inferred from direct assay	25063885	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	10655584	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	26158630	GOA
located in leading edge membrane	IDA IDA: Inferred from direct assay	19573808	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10655584	GOA
located in tight junction	IDA IDA: Inferred from direct assay	27815408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA2 Protein Structure

Ephrin_lbd

fn3

EphA2_TM

Pkinase_Tyr

SAM_1

0
200
400
600
800
976 a.a.

Protein Preferred Names	Protein Names
ephrin type-A receptor 2	epithelial cell receptor protein tyrosine kinase

EPHA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	EPHA2	P29317	EPHA7	Homo sapiens	Q15375	Anti Bait CoIP	22036564
Intra	EPHA2	P29317	EPHA7	Homo sapiens	Q15375	Anti Tag CoIP	33961781
Intra	EPHA2	P29317	EPHA7	Homo sapiens	Q15375	Comigration in SDS	22036564
Intra	EPHA2	P29317	INPPL1	Homo sapiens	O15357-1	ITC	22244754
Intra	EPHA2	P29317	INPPL1	Homo sapiens	O15357-1	NMR	22244754
Intra	EPHA2	P29317	EFNA5	Homo sapiens	P52803	Pull Down	20505120
Intra	EPHA2	P29317	EFNA5	Homo sapiens	P52803	Light Scattering	20228801
Intra	EPHA2	P29317	EFNA5	Homo sapiens	P52803	GMS	20505120
Intra	EPHA2	P29317	EFNA5	Homo sapiens	P52803	GMS	20228801
Intra	EPHA2	P29317	EFNA5	Homo sapiens	P52803	X-Ray Diffraction	20228801
Intra	EPHA2	P29317	EFNA5	Homo sapiens	P52803	X-Ray Diffraction	20505120
Intra	EPHA2	P29317	PTPN11	Homo sapiens	Q06124	BioID	35384245
Intra	EPHA2	P29317	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	10655584
Intra	EPHA2	P29317	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	EPHA2	P29317	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	EPHA2	P29317	EPHA6	Homo sapiens	Q9UF33	Anti Tag CoIP	35384245
Intra	EPHA2	P29317	EPHA6	Homo sapiens	Q9UF33	Anti Tag CoIP	33961781
Intra	EPHA2	P29317	EFNA1	Homo sapiens	P20827	Anti Tag CoIP	19573808
Intra	EPHA2	P29317	EFNA1	Homo sapiens	P20827	X-Ray Diffraction	20505120
Intra	EPHA2	P29317	EFNA1	Homo sapiens	P20827	GMS	19525919

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHA2 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P70336	EphA2 Protein, Human (HEK293, His)	P29317/NP_004422.2 (A24-N534)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72991	EphA2 Protein, Human (Active, sf9, His-GST)	P29317 (L585-I976)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72992	EphA2 Protein, Human (Biotinylated, HEK293, His-Avi)	NP_004422.2 (A24-N534)	≥ 95%, as determined by reducing SDS-PAGE.

EPHA2 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81594	EphA2 Antibody (YA1339)	WB, ICC/IF, IP, FC	Human
HY-P85138	EphA2 Antibody (YA4830)	WB, IHC-P, ELISA	Human
HY-P85138A	EphA2 Antibody (YA4830)(PBS only)	WB, IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Cataract 6, Multiple Types	Ctpp1 Cataract 6 Multiple Types CTRCT6 Cataract, Posterior Polar, 1 Arcc2 Cataract, Age-Related Cortical, 2 Ctpa Ctpp Age Related Cortical Cataract 2 Posterior Polar Cataract 1 Posterior Polar Cataract, 1 Age-Related Cortical Cataract 2 Cataract Posterior Polar 1
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Aniridia 1	Aniridia Congenital Aniridia AN1 An Cataract With Late-Onset Corneal Dystrophy Aplasia Of Iris Absent Iris Irideremia Aniridia Ii, Formerly An2, Formerly An2 Aniridia Type Ii Aniridia, Type 1 An-1 Absence Of Iris Agenesis Of Iris Congenital Absence Of Iris Hereditary Aniridia Sporadic Aniridia
Early-Onset Posterior Subcapsular Cataract
Early-Onset Posterior Polar Cataract
Cataract 44	CTRCT44 Total Early-Onset Cataract Cataract 44 And Hypotrichosis Cataract And Hypotrichosis Cataract, Type 44
Early-Onset Nuclear Cataract
Cortical Senile Cataract
Posterior Polar Cataract	Cataract, Posterior Polar
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Glioma
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Cataract 7	Cca1 CTRCT7 Cerulean Cataract Cataract 7, Cerulean Type Cataract, Congenital, Cerulean Type, 1 Cerulean Type Cataract 7 Congenital Cerulean Type Cataract 1 Cataract, Congenital, Blue Dot Type 1 Cataract, Congenital, Cerulean Type 1 Blue-Dot Cataract
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (32)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-13258A	NVP-BHG712	Inhibitor	99.71%	Unkown
HY-133178	Urolithin D		99.72%	Unkown
HY-13258	NVP-BHG712 isomer		99.32%	Unkown
HY-123607	UniPR129	Antagonist	99.23%	Unkown
HY-P3717	Targefrin		99.80%	Unkown
HY-124813	PDZ1i	Inhibitor	99.29%	Unkown
HY-169849	EphA2 antagonist 1	Inhibitor	97.4%	Unkown
HY-147637	EphA2 agonist 1	Agonist	98.57%	Unkown
HY-P10412	A11	Inhibitor	98.49%	Unkown
HY-170517	PKMYT1-IN-8	Inhibitor	99.31%	Unkown
HY-146375	UniPR505	Antagonist	99.68%	Unkown
HY-157019	UniPR1447	Antagonist	99.46%	Unkown
HY-P10579	123B9	Agonist	99.67%	Unkown
HY-W078239	EPHA4 antagonist-1	Antagonist	95.61%	Unkown
HY-10654	EphB4-IN-2	Inhibitor	/	Unkown
HY-133178R	Urolithin D (Standard)		/	Unkown
HY-146141	EphA2 agonist 2	Agonist	98.64%	Unkown
HY-14979	ML786	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-157020	UniPR1449	Antagonist	/	Unkown
HY-159174	EPHA2/A4/GAK-IN-1	Inhibitor	/	Unkown
HY-161170	Antimalarial agent 36	Inhibitor	/	Unkown
HY-163835	UniPR1454	Antagonist	/	Unkown
HY-178721	Lithocholic amide-C2-N(didecane)	Inhibitor	/	Unkown
HY-18692	Multi-kinase-IN-12	Inhibitor	/	Unkown
HY-P10412A	A11 acetate	Inhibitor	98.48%	Unkown
HY-P11015	(123B9)2-Motif	Agonist	/	Unkown
HY-P11018	(123B9)2-L2-PTX	Agonist	/	Unkown
HY-RS04426	EPHA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-171175	UniPR500	Antagonist	/	Unkown
HY-RS16753	Epha2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23192	Epha2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P990627	Anti-EphA2 Antibody (1C1)	Inhibitor	99.9%	Unkown
HY-P991577	DS-8895	Inhibitor	97.19%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EPHA2	VGNC	VGNC:28534
Mus musculus	EPHA2	MGD	MGI:95278
Rattus norvegicus	EPHA2	RGD	RGD:1307204
Canis familiaris	EPHA2	VGNC	VGNC:40405
Macaca mulatta	EPHA2	VGNC	VGNC:72235
Felis catus	EPHA2	VGNC	VGNC:61902
Others	EPHA2	NCBI