DS-8895  (Synonyms: DS-8895A)

DS-8895(DS-8895A) is an anti-EphA2 monoclonal antibody with specific binding to EphA2 receptors and EphA2-expressing cells. DS-8895, when conjugated with ⁸⁹Zr, ¹¹¹In, or ¹²⁵I, supports molecular imaging of EphA2 expression in xenograft models. DS-8895 allows noninvasive measurement of EphA2 expresssion in tumors in vivo.^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

DS-8895 (10 μg/mL) confirms high EphA2 expression on MDA-MB-231 human breast carcinoma cells via flow cytometry^[2].
DS-8895 (Radiolabeled ¹²⁵I-DS-8895a, ¹¹¹In-CHX-A″-DTPA-DS-8895a, ⁸⁹Zr-Df-Bz-NCS-DS-8895a) exhibit high radiochemical purity, specific immunoreactivity with MDA-MB-231 cells, and measurable EphA2 binding affinity and site density^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DS-8895 (Radiolabeled) (0.25 mg/kg; i.v.; single dose) demonstrates specific, time-dependent uptake in EphA2-positive breast cancer xenografts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1969  [NCBI]

P29317

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

147.20 kDa

Liquid

Colorless to light yellow

N/A

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Giorgio C, et al. Ephrin or not? Six tough questions on Eph targeting. Expert Opin Ther Targets. 2020;24(5):403-415.  [Content Brief]

  [2]. Burvenich IJ, et al. Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a. J Nucl Med. 2016;57(6):974-980.  [Content Brief]