DS-8895
Based on 1 Customer Validation
DS-8895(DS-8895A) is an anti-EphA2 monoclonal antibody with specific binding to EphA2 receptors and EphA2-expressing cells. DS-8895, when conjugated with 89Zr, 111In, or 125I, supports molecular imaging of EphA2 expression in xenograft models. DS-8895 allows noninvasive measurement of EphA2 expresssion in tumors in vivo..
For research use only. We do not sell to patients.
- Purity: 97.19%
- Molecular Weight:147.20 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
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EPHA2 |
DS-8895 (10 μg/mL) confirms high EphA2 expression on MDA-MB-231 human breast carcinoma cells via flow cytometry[2].
DS-8895 (Radiolabeled 125I-DS-8895a, 111In-CHX-A″-DTPA-DS-8895a, 89Zr-Df-Bz-NCS-DS-8895a) exhibit high radiochemical purity, specific immunoreactivity with MDA-MB-231 cells, and measurable EphA2 binding affinity and site density[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:athymic BALB/c nu/nu (5-6 week old female)[2]
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Dosage:0.25 mg/kg
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Administration:i.v.; single dose
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Result:Reached tumor uptake of 7.58 %ID/g at day 2 and 6.73 %ID/g at day 7 for 89Zr-Df-Bz-NCS-DS-8895a.
Showed significantly lower uptake than in EphA2-positive MDA-MB-231 xenografts at the same time points (21.52 %ID/g and 23.64 %ID/g, respectively; P<0.0001).
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 147.20 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
DS-8895A
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Giorgio C, et al. Ephrin or not? Six tough questions on Eph targeting. Expert Opin Ther Targets. 2020;24(5):403-415. [Content Brief]
[2]. Burvenich IJ, et al. Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a. J Nucl Med. 2016;57(6):974-980. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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