2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. UniPR505

UniPR505 (Compound 14) is an EphA2 antagonist with an IC50 of 0.95 µM. UniPR505 displays anti-angiogenic properties.

For research use only. We do not sell to patients.

UniPR505

UniPR505 Chemical Structure

CAS No. : 2938227-14-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Customer Review

Based on 1 publication(s) in Google Scholar

UniPR505 Related Antibodies

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EphB EphA

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

UniPR505 (Compound 14) is an EphA2 antagonist with an IC50 of 0.95 µM. UniPR505 displays anti-angiogenic properties[1].

IC50 & Target

IC50: 0.95 µM (EphA2), 4.4 µM (EphA5), 4.5 µM (EphA3), 6.4 µM (EphA4), 7.7 µM (EphA8), 11 µM (EphB3), 14 µM (EphB2), 18 µM (EphA6)[1]
Cellular Effect
Cell Line Type Value Description References
HUVEC IC50
3 μM
Compound: 14
Antiangiogenic activity in HUVEC assessed as reduction in number of polygons formation after 16 hrs by matrigel-based microscopic analysis
Antiangiogenic activity in HUVEC assessed as reduction in number of polygons formation after 16 hrs by matrigel-based microscopic analysis
[PMID: 32000051]
Molecular Weight

647.89

Formula

C39H57N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@@H]([C@]4(CC[C@]3([H])[C@]1(CC[C@H](C2)OC(NCC)=O)C)C)[C@@H](CCC(N[C@@H](CC5=CNC6=C5C=CC=C6)CC(O)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (154.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5435 mL 7.7174 mL 15.4347 mL
5 mM 0.3087 mL 1.5435 mL 3.0869 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.68%

SDS (251 KB)

COA (250 KB) HNMR (511 KB) RP-HPLC (255 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5435 mL 7.7174 mL 15.4347 mL 38.5868 mL
5 mM 0.3087 mL 1.5435 mL 3.0869 mL 7.7174 mL
10 mM 0.1543 mL 0.7717 mL 1.5435 mL 3.8587 mL
15 mM 0.1029 mL 0.5145 mL 1.0290 mL 2.5725 mL
20 mM 0.0772 mL 0.3859 mL 0.7717 mL 1.9293 mL
25 mM 0.0617 mL 0.3087 mL 0.6174 mL 1.5435 mL
30 mM 0.0514 mL 0.2572 mL 0.5145 mL 1.2862 mL
40 mM 0.0386 mL 0.1929 mL 0.3859 mL 0.9647 mL
50 mM 0.0309 mL 0.1543 mL 0.3087 mL 0.7717 mL
60 mM 0.0257 mL 0.1286 mL 0.2572 mL 0.6431 mL
80 mM 0.0193 mL 0.0965 mL 0.1929 mL 0.4823 mL
100 mM 0.0154 mL 0.0772 mL 0.1543 mL 0.3859 mL
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UniPR505 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UniPR5052938227-14-4UniPR 505UniPR-505Ephrin Receptorglioblastomaanti-angiogenicanticancerEphA3EphA4EphA5EphA6EphA8EphB2EphB3Inhibitorinhibitorinhibit

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