UniPR505
Based on 1 Customer Validation
UniPR505 (Compound 14) is an EphA2 antagonist with an IC50 of 0.95 µM. UniPR505 displays anti-angiogenic properties.
For research use only. We do not sell to patients.
- Purity: 99.68%
- CAS No.: 2938227-14-4
- Formula: C39H57N3O5
- Molecular Weight:647.89
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.95 µM (EphA2), 4.4 µM (EphA5), 4.5 µM (EphA3), 6.4 µM (EphA4), 7.7 µM (EphA8), 11 µM (EphB3), 14 µM (EphB2), 18 µM (EphA6)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
3 μM
Compound: 14
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Antiangiogenic activity in HUVEC assessed as reduction in number of polygons formation after 16 hrs by matrigel-based microscopic analysis
Antiangiogenic activity in HUVEC assessed as reduction in number of polygons formation after 16 hrs by matrigel-based microscopic analysis
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[PMID: 32000051] |
Chemical Information
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CAS No. 2938227-14-4
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Appearance Solid
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Molecular Weight 647.89
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Formula C39H57N3O5
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Color White to off-white
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SMILES
[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@@H]([C@]4(CC[C@]3([H])[C@]1(CC[C@H](C2)OC(NCC)=O)C)C)[C@@H](CCC(N[C@@H](CC5=CNC6=C5C=CC=C6)CC(O)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (154.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5435 mL | 7.7174 mL | 15.4347 mL | 38.5868 mL |
| 5 mM | 0.3087 mL | 1.5435 mL | 3.0869 mL | 7.7174 mL | |
| 10 mM | 0.1543 mL | 0.7717 mL | 1.5435 mL | 3.8587 mL | |
| 15 mM | 0.1029 mL | 0.5145 mL | 1.0290 mL | 2.5725 mL | |
| 20 mM | 0.0772 mL | 0.3859 mL | 0.7717 mL | 1.9293 mL | |
| 25 mM | 0.0617 mL | 0.3087 mL | 0.6174 mL | 1.5435 mL | |
| 30 mM | 0.0514 mL | 0.2572 mL | 0.5145 mL | 1.2862 mL | |
| 40 mM | 0.0386 mL | 0.1929 mL | 0.3859 mL | 0.9647 mL | |
| 50 mM | 0.0309 mL | 0.1543 mL | 0.3087 mL | 0.7717 mL | |
| 60 mM | 0.0257 mL | 0.1286 mL | 0.2572 mL | 0.6431 mL | |
| 80 mM | 0.0193 mL | 0.0965 mL | 0.1929 mL | 0.4823 mL | |
| 100 mM | 0.0154 mL | 0.0772 mL | 0.1543 mL | 0.3859 mL |
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