EPHA2/A4/GAK-IN-1
EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of EPHA2/EPHA4 and GAK with KD values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. EPHA2/GAK-IN-1 shows an extrapolated half-life time of 4.6 h in a microsomal stability assay. EPHA2/GAK-IN-1 shows antiviral activity and prevents dengue virus infection of Huh7 liver cells.
For research use only. We do not sell to patients.
- Formula: C20H20BrN5O3S
- Molecular Weight:490.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GAK 19.2 nM (Kd) |
GAK 27 nM (EC50) |
ABL1 >50000 nM (EC50) |
FGFR1 18000 nM (EC50) |
FLT1 33000 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>10 μM
Compound: 55
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Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by alamar blue reagent based analysis
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by alamar blue reagent based analysis
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[PMID: 39028937] |
Chemical Information
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Molecular Weight 490.37
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Formula C20H20BrN5O3S
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SMILES
BrC1=CC=C(C=C1OC)C2=C(NCCCNS3(=O)=O)N=C(N=C2)NC4=CC=CC3=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EPHA2/A4/GAK-IN-1 Related Classifications
HY-159174 Related Classifications
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