2. Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Anti-infection
  3. Ephrin Receptor Cyclin G-associated Kinase (GAK) Dengue Virus
  4. EPHA2/A4/GAK-IN-1

EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of EPHA2/EPHA4 and GAK with KD values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. EPHA2/GAK-IN-1 shows an extrapolated half-life time of 4.6 h in a microsomal stability assay. EPHA2/GAK-IN-1 shows antiviral activity and prevents dengue virus infection of Huh7 liver cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

EPHA2/A4/GAK-IN-1

EPHA2/A4/GAK-IN-1 構造式

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

EPHA2/A4/GAK-IN-1 関連抗体

Top Publications Citing Use of Products

Ephrin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
EphB EphA

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

EPHA2/A4/GAK-IN-1 (compound 55) is a potent inhibitor of EPHA2/EPHA4 and GAK with KD values of 180.5 nM for EPHA2 and 19.2 nM for GAK, respectively. EPHA2/GAK-IN-1 shows an extrapolated half-life time of 4.6 h in a microsomal stability assay. EPHA2/GAK-IN-1 shows antiviral activity and prevents dengue virus infection of Huh7 liver cells[1].

IC50 & Target[1]

GAK

19.2 nM (Kd)

GAK

27 nM (EC50)

ABL1

>50000 nM (EC50)

FGFR1

18000 nM (EC50)

FLT1

33000 nM (EC50)

Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
> 10 μM
Compound: 55
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by alamar blue reagent based analysis
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by alamar blue reagent based analysis
[PMID: 39028937]
分子量

490.37

分子式

C20H20BrN5O3S
SMILES

BrC1=CC=C(C=C1OC)C2=C(NCCCNS3(=O)=O)N=C(N=C2)NC4=CC=CC3=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

EPHA2/A4/GAK-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPHA2/A4/GAK-IN-1Ephrin ReceptorCyclin G-associated Kinase (GAK)Dengue VirusAuxilin 2DENVEPHA2half-lifemicrosomal stability assayHuh7Inhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
EPHA2/A4/GAK-IN-1
製品番号:
HY-159174
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.