CDK20 - cyclin dependent kinase 20 Gene

Also Known as P42; CCRK; CDCH; PNQALRE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23552

About CDK20

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:87,966,441-87,974,533 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 26 paralogues. Broad expression in testis (RPKM 10.2), adrenal (RPKM 7.6) and 24 other tissues.

Summary

The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]

CDK20 Products (5)

mRNA Protein Name
NM_001039803.3 NP_001034892.1 cyclin-dependent kinase 20 isoform 3
NM_001170639.2 NP_001164110.1 cyclin-dependent kinase 20 isoform 4
NM_001170640.2 NP_001164111.1 cyclin-dependent kinase 20 isoform 5
NM_012119.5 NP_036251.2 cyclin-dependent kinase 20 isoform 2
NM_178432.4 NP_848519.1 cyclin-dependent kinase 20 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
21986944 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK20 Protein Structure

Pkinase

Pkinase: Protein kinase domain (4 - 288)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 20

  • CAK-kinase p42

CDK20 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
CDK20 Q8IZL9 TRIM2 Homo sapiens Q9C040
Y2H Prey Pooling
26871637
Intra
CDK20 Q8IZL9 TRIM2 Homo sapiens Q9C040
Validated Y2H
26871637
Intra
CDK20 Q8IZL9 TRIM2 Homo sapiens Q9C040
Y2H Array
26871637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Endocrine-Cerebroosteodysplasia

  • Endocrine-Cerebro-Osteodysplasia Syndrome

  • ECO

  • Eco Syndrome
Nephrotic Syndrome, Type 22

  • NPHS22

  • Nephrotic Syndrome Type 22

  • Nephrotic Syndrome 22
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS28035 Cdk20 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDK20 VGNC VGNC:27124
Macaca mulatta CDK20 VGNC VGNC:71070
Felis catus CDK20 VGNC VGNC:60698
Rattus norvegicus CDK20 RGD RGD:1305219
Canis familiaris CDK20 VGNC VGNC:39052
Mus musculus CDK20 MGD MGI:2145349
Others CDK20 NCBI