GPLGVRG
GPLGVRG is an MMP13-responsive linker peptide. GPLGVRG can be hydrolyzed by MMP13, which in turn triggers micellar disintegration, loss of amphipathicity, and increases the chondrocyte uptake rate of the related delivery system. GPLGVRG can be used in the research of osteoarthritis.
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- No. CAS: 915404-04-5
- Fòrmula: C28H50N10O8
- Peso molecular:654.76
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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MMP13 |
The GPLGVRG peptide is selectively cleaved by MMP13 present in IL-1β-stimulated osteoarthritis (OA) chondrocytes, generating a detectable fluorescent signal via FRET substrate cleavage, and this signal is inhibitable by MMP inhibitors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 12 weeks old, 300 to 350 g, ACLT+DMM induced knee OA)[1]
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Dosage:micelle:exosome protein mass ratio 10:1; 250 μM DHA
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Administration:intra-articular; single dose
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Result:Reduced Osteoarthritis Research Society International.
Preserved cartilage thickness.
Increased chondrocyte number.
Reduced positive staining for ADAMTS5 to 17.0% versus 79.3% in OA control.
Reduced positive staining for MMP13 to 14.7% versus 72.1% in OA control.
Increased trabecular bone mineral density to 1.4 versus 1.3 in OA control.
Increased trabecular thickness to 0.2 mm versus 0.1 mm in OA control.
Increased bone volume fraction to 45.2% versus 33.9% in OA control.
Penetrated ex vivo rat femoral head cartilage to 74.0 μm versus 32.4 μm for unmodified exosomes at 48 h.
Penetrated ex vivo rat femoral head cartilage to 155.0 μm versus 36.3 μm for unmodified exosomes at 72 h.
Chemical Information
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No. CAS 915404-04-5
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Peso molecular 654.76
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Fòrmula C28H50N10O8
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Sequence
Gly-Pro-Leu-Gly-Val-Arg-Gly
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Sequence Shortening
GPLGVRG
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPLGVRG Related Classifications
HY-P11800 Related Classifications
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