LD-38
LD-38 is a drug-linker conjugate for ADC. LD-38 consists of a topoisomerase 1 inhibitor (Exatecan) (HY-13631) and a highly hydrophilic stable and cleavable linker. LD-38 can be used for synthesis of ADCs, such as KA-3123-LD38.
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- No. CAS: 3094583-35-1
- Fòrmula: C67H87FN10O20S
- Peso molecular:1403.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Drug-Linker Conjugates for ADC
MoreVer todos los productos específicos de isoformas Topoisomerase
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Topoisomerase I |
In Vitro
KA-3123-LD38 is a bispecific ADC targeting EGFR and B7H3, built on the LD-38 platform. In various xenograft mouse models, it has demonstrated strong growth inhibitory effects on non-small cell lung cancer, esophageal squamous cell carcinoma, colorectal cancer, and gastric cancer, etc. The current toxicity studies indicate that it has favorable safety characteristics[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 3094583-35-1
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Peso molecular 1403.53
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Fòrmula C67H87FN10O20S
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SMILES
O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@H](C(NC2=CC=C(COC(N[C@H]3CCC(C(C)=C(F)C=C4N=C5C6=CC7=C8COC([C@](CC)7O)=O)=C4C3=C5CN6C8=O)=O)C=C2)=O)CCC(NCC[N+](C)(CCCS([O-])(=O)=O)C)=O)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LD-38 Related Classifications
HY-177495 Related Classifications
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