3094583-35-1
Chemical Structure
LD-38
- CAS No.: 3094583-35-1
- Formula:C67H87FN10O20S
- Molecular Weight:1403.53
IUPAC Name: (21S,24R)-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-24-((4-(((((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)carbamoyl)oxy)methyl)phenyl)carbamoyl)-21-isopropyl-31,31-dimethyl-3,19,22,27-tetraoxo-7,10,13,16-tetraoxa-4,20,23,28,31-pentaazatetratriacontan-31-ium-34-sulfonate
InChIKey: VNYCOOMUHCTISP-GFFSSVBXSA-N
SMILES: O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@H](C(NC2=CC=C(COC(N[C@H]3CCC(C(C)=C(F)C=C4N=C5C6=CC7=C8COC([C@](CC)7O)=O)=C4C3=C5CN6C8=O)=O)C=C2)=O)CCC(NCC[N+](C)(CCCS([O-])(=O)=O)C)=O)=O)=O)=O
Biological Activity: LD-38 is a drug-linker conjugate for ADC. LD-38 consists of a topoisomerase 1 inhibitor (Exatecan) (HY-13631) and a highly hydrophilic stable and cleavable linker. LD-38 can be used for synthesis of ADCs, such as KA-3123-LD38[1][2].
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LD-38 | LD-38 is a drug-linker conjugate for ADC. LD-38 consists of a topoisomerase 1 inhibitor (Exatecan) (HY-13631) and a highly hydrophilic stable and cleavable linker. LD-38 can be used for synthesis of ADCs, such as KA-3123-LD38. | |||||||||||||||||||||
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Keywords
