Loncastuximab tesirine
Based on 1 Customer Validation
Loncastuximab tesirine is a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC). The antibody portion is Loncastuximab (HY-P99711), and the drug-linker conjugate for ADC is Tesirine (HY-128952). Once bound to CD19 on the cell membrane, loncastuximab tesirine is rapidly internalised and triggers cell death. Loncastuximab tesirin induces cell apoptosis, it can be used for the research of diffuse large B-cell lymphoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 95.22%
- No. CAS: 1879918-31-6
- Peso molecular:147000 (average)
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-132253
Polatuzumab vedotin
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HY-P99107A
Brentuximab vedotin (solution)
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HY-P9985
Disitamab vedotin
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HY-P9921
Trastuzumab emtansine
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HY-132253A
Polatuzumab vedotin (solution)
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HY-138298
Trastuzumab deruxtecan (solution)
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HY-132258A
Mirvetuximab soravtansine (solution)
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HY-132254A
Sacituzumab govitecan (solution)
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HY-P3239
Belantamab mafodotin
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HY-152963
Tisotumab vedotin
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HY-P9921A
Trastuzumab emtansine (solution)
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HY-132254
Sacituzumab govitecan
Actividad biológica
Loncastuximab tesirine reduces cell viability and induces apoptosis of three human-derived, CD19 and CD79b-positive NHL cell lines (WSU-DLCL2, TMD8 and Ramos) and shows better effects with the combination of polatuzumab vedotin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1879918-31-6
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Appearance Liquid
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Peso molecular 147000 (average)
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Color Colorless to light yellow
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SMILES
[Loncastuximab tesirine]
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Synonyms
Loncastuximab tesirine-lpyl; ADCT-402
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Envío
Shipping with dry ice.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Loncastuximab tesirine Related Classifications
HY-P99349 Related Classifications
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