2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Belantamab mafodotin

Belantamab mafodotin  (Synonyms: GSK2857916; Belantamab mafodotin-blm)

Cat. No.: HY-P3239 Purity: 99.60%
COA

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Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. Belantamab mafodotin has anti-myeloma activity.

For research use only. We do not sell to patients.

Belantamab mafodotin Chemical Structure

Belantamab mafodotin Chemical Structure

CAS No. : 2050232-20-5

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Based on 1 publication(s) in Google Scholar

Belantamab mafodotin Related Antibodies

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Description

Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. Belantamab mafodotin has anti-myeloma activity[1][2].

In Vitro

Belantamab mafodotin binds to human BCMA protein with a Kd of 1 nM[2].
Belantamab mafodotin induces G2/M arrest in multiple myeloma cells in a dose and time dependent manner[2].
Belantamab mafodotin signifcantly promotes phagocytosis of multiple myeloma cells by human macrophages derived from macrophage colony-stimulating factor-stimulated monocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Belantamab mafodotin Related Antibodies
In Vivo

Belantamab mafodotin signifcantly improves survival compared to vehicle in mice harbouring OPM2 tumours[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice harbouring OPM2 tumours[2]
Dosage: 4 mg/kg
Administration: IP, twice weekly for 4 doses
Result: Signifcantly improves survival compared to vehicle.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Belantamab mafodotin]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.60%

COA (231 KB) RP-HPLC (251 KB)

Handling Instructions (2659 KB)
References
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Belantamab mafodotin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belantamab mafodotin2050232-20-5GSK2857916 Belantamab mafodotin-blmGSK 2857916GSK-2857916Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesmultiple myelomaDREAMM-2immunoconjugateB-cell maturation antigenanti-myelomaInhibitorinhibitorinhibit

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