MN-05
MN-05 is a dual neuroprotective and vasodilatory NMDA receptor inhibitor.MN-05 blocks calcium influx, reduces free radical production, and maintains mitochondrial membrane potential in cortical neurons exposed to glutamate.MN-05 dilates aortic rings against phenylephrine-induced contraction.MN-05 protects neurons against glutamate-induced injury in vitro.MN-05 can be used for the research of neurodegenerative diseases.
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- No. CAS: 1835197-63-1
- Fòrmula: C13H22N2O3
- Peso molecular:254.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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NMDA Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cerebellar granule neurone | EC50 |
10.68 μM
Compound: MN-05
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Neuroprotective activity against glutamate-induced excitotoxicity in mouse primary cerebellar granule neurons assessed as increase in cell viability preincubated for 2 hrs followed by glutamate challenge measured after 24 hrs by MTT assay
Neuroprotective activity against glutamate-induced excitotoxicity in mouse primary cerebellar granule neurons assessed as increase in cell viability preincubated for 2 hrs followed by glutamate challenge measured after 24 hrs by MTT assay
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[PMID: 30108699] |
MN-05 (0.1-100 μM; 24 h) potently protects primary cerebellar granule neurons against glutamate-induced injury, with an EC50 of 10.68 μM[1].
MN-05 (5-45 μM; 24 h) protects primary rat cortical neurons against glutamate-induced injury in vitro in a concentration-dependent manner[1].
MN-05 (5-15 μM; 5 min) inhibits glutamate-induced intracellular calcium influx in primary cortical neurons[1].
MN-05 (5-45 μM; 12 h) concentration-dependently inhibits the production of reactive oxygen/nitrogen species in primary cortical neurons induced by glutamate[1].
MN-05 (5-45 μM; 12 h) maintains mitochondrial membrane potential in a concentration-dependent manner and inhibits glutamate-induced mitochondrial dysfunction in primary cortical neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1835197-63-1
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Peso molecular 254.33
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Fòrmula C13H22N2O3
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SMILES
NC(C1)(CC(C2)(C3)CC)CC2CC13CO[N+]([O-])=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MN-05 Related Classifications
HY-126939 Related Classifications
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