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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
196 Results for "
AI
" in MedChemExpress (MCE) Product Catalog:
Products (196)
196 Results for "AI" in MCE Product Catalog:
Referencia número: HY-P2605
No. CAS: 117620-76-5
Áreas de investigación:
Referencia número: HY-RI01642A
hsa-miR-548ai antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
Referencia número: HY-RS17033
Target:
Áreas de investigación:
Arg1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Arg1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-113066B
No. CAS: 103192-39-8
Synonyms: GDP ditromethamine
Áreas de investigación:
Guanosine 5'-diphosphate ditromethamine is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K + channel. Guanosine 5'-diphosphate ditromethamine is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate ditromethamine can be used in the research of inflammation, such as anemia of inflammation (AI) .
Referencia número: HY-113066S2
Synonyms: GDP-d13 dilithium
Referencia número: HY-113066S3
Synonyms: GDP-13C10,15N5 dilithium
Referencia número: HY-145462
No. CAS: 1400974-23-3
N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a potent inhibitor of AhyI. AhyI (expressing acylhomoserine lactone) is responsible for the biosynthesis of autoinducer-1 (AI-1), commonly referred to as a quorum sensing (QS) signaling molecule, which plays an essential role in bacterial communication. N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a competitive inhibitor of AI-1 biosynthesis .
Referencia número: HY-N14254
No. CAS: 93397-17-2
Category:
Referencia número: HY-N14258
No. CAS: 98474-20-5
Category:
Target:
Referencia número: HY-N14259
No. CAS: 98495-38-6
Category:
Target:
Referencia número: HY-178781
Antibacterial agent 297 (Compound A40), an antibacterial agent, is a Lsrk inhibitor (IC50: 0.40 μM; KD: 3.79 μM). Antibacterial agent 297 inhibits biofilm formation and bacterial motility and changes biofilm morphology through AI-2 QS inhibition rather than direct antibacterial effects. Antibacterial agent 297 has favorable oral PK properties .
Referencia número: HY-101434A
No. CAS: 77590-95-5
Synonyms: AI-27303 hydrochloride; ICI-72222 hydrochloride
Target:
Áreas de investigación:
Cetamolol hydrochloride is classified as a potent β1-blocker with intrinsic sympathomimetic activity and cardioselectivity. Low and medium doses of Cetamolol and Atenolol produce a more prolonged inhibitory effect than the same doses of Propranolol and Dexpropranolol.
Referencia número: HY-129206
No. CAS: 65049-45-8
Synonyms: RU-24476
Target:
Áreas de investigación:
Locicortolone (RU-24476) is a synthetic steroid compound. Locicortolone inhibits Angiotensin I (AI) induced pressor response. Locicortolone can be used in antihypertensive studies .
Referencia número: HY-137628
No. CAS: 156816-35-2
Sp-8-PIP cAMP sodium is a non-corresponding isomer of 8-Piperidino-cAMP. 8-Piperidino-cAMP binds with high affinity to site A of the regulatory subunit of cAMP-dependent protein kinase type I (AI). Sp-8-PIP cAMP sodium can be used as an antagonist of cAMP-induced activation .
Referencia número: HY-145359
No. CAS: 2100145-31-9
Áreas de investigación:
eIF4A3-IN-5 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A), such as eIF4AI and eIF4AII. eIF4A3-IN-5 has the potential for the research of eIF4A dependent diseases, including the research of cancer (extracted from patent US20170145026A1) .
Referencia número: HY-179111
No. CAS: 3034320-17-4
Target:
Áreas de investigación:
HPK1-IN-64 is a potent, selective, and orally active HPK1 inhibitor with an IC50 value of 1.9 nM. HPK1-IN-64 exhibits selectivity exceeding 100-fold, 80-fold, 300-fold, and 350-fold against off-target kinases such as GLK, MAP4K5, TBK1, and TNIK, respectively. HPK1-IN-64 inhibits SLP76 protein phosphorylation and IL-2 secretion. HPK1-IN-64 may be used in cancer research, such as for colorectal cancer .
Referencia número: HY-117555
No. CAS: 1415477-76-7
Áreas de investigación:
4010B-30 is a upregulator of apolipoprotein A-I (ApoA-I). 4010B-30 regulates ApoA-I gene expression through activation of PPARγ. 4010B-30 promotes cholesterol efflux and ABCA1 expression. 4010B-30 protects against atherosclerotic lesion development in ApoE -/- mice .
Referencia número: HY-P992177
Target:
Áreas de investigación:
Referencia número: HY-184907
Target:
Áreas de investigación:
AI10-m15 is a tyrosinase inhibitor, with IC50 values of 0.019 μM (using L-DOPA (HY-N0304) as the substrate) and 0.02 μM (using L-Tyrosine (HY-N0473) as the substrate) against mushroom tyrosinase. AI10-m15 inhibits intracellular melanin production and reduces head pigmentation in zebrafish embryos. AI10-m15 can be used for the research of hyperpigmentation disorders .
Referencia número: HY-184909
Target:
Áreas de investigación:
AI10-a2 is a tyrosinase (tyrosinase) inhibitor, with IC50 values of 0.92 μM against mushroom tyrosinase using L-DOPA (HY-N0304) as the substrate and 0.68 μM using L-Tyrosine (HY-N0473) as the substrate. AI10-a2 inhibits intracellular melanin (melanin) production and reduces head pigmentation in zebrafish embryos. AI10-a2 can be used for the research of hyperpigmentation disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
