1415477-76-7
1415477-76-7
Chemical Structure
4010B-30
- CAS No.: 1415477-76-7
- Formula:C17H20F4N2O
- Molecular Weight:344.35
IUPAC Name: (4-fluoro-3-(trifluoromethyl)phenyl)(8-methyl-2,8-diazaspiro[4.5]decan-2-yl)methanone
InChIKey: WJCSOVLPWXDKAY-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(F)C(C(F)(F)F)=C1)N2CC3(CCN(C)CC3)CC2
Biological Activity: 4010B-30 is a upregulator of apolipoprotein A-I (ApoA-I). 4010B-30 regulates ApoA-I gene expression through activation of PPARγ. 4010B-30 promotes cholesterol efflux and ABCA1 expression. 4010B-30 protects against atherosclerotic lesion development in ApoE-/- mice[1][2].
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4010B-30 | 4010B-30 is a upregulator of apolipoprotein A-I (ApoA-I). 4010B-30 regulates ApoA-I gene expression through activation of PPARγ. 4010B-30 promotes cholesterol efflux and ABCA1 expression. 4010B-30 protects against atherosclerotic lesion development in ApoE-/- mice. | |||||||||||||||||||||
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References
- [1]. Du Y, et al. A novel compound 4010B-30 upregulates apolipoprotein A-I gene expression through activation of PPARγ in HepG2 cells. Atherosclerosis. 2015 Apr;239(2):589-98. [Content Brief]
- [2]. Hong, Bin et al. Effects of 4010B-30, A novel small molecule, on the endogenous apolipoprotein A-I expression and the development of atherosclerosis. Atherosclerosis, Volume 263, e74
Keywords
