Thienodolin
Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation.
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- No. CAS: 149127-27-5
- Fòrmula: C11H7ClN2OS
- Peso molecular:250.70
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Thienodolin (6.25-50 μM, 15 min pretreatment) inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 cells (IC50 = 17.2 μM)[1].
Thienodolin (6.25-50 μM, 5-18 h) suppresses iNOS expression in a dose-dependent manner at both mRNA and protein levels in LPS-stimulated RAW 264.7 cells[1].
Thienodolin (6.25-50 μM, 15 min pretreatment) blocks the degradation of IκBα, reduces the phosphorylation level of STAT1 at Tyr701 and attenuates NF-κB p65 accumulation in the nucleus in LPS-stimulated RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-stimulated RAW 264.7 cells
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Concentration:6.25, 12.5, 25, 50 μM
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Incubation Time:15 min pretreatment
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Result:Blocked the degradation of IκBα.
Reduced the phosphorylation level of STAT1 at Tyr701.
Attenuated NF-κB p65 accumulation in the nucleus.
Chemical Information
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No. CAS 149127-27-5
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Peso molecular 250.70
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Fòrmula C11H7ClN2OS
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SMILES
O=C(C1=CC2=C(NC3=C2C=CC(Cl)=C3)S1)N
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Synonyms
MJ 286A
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Structure Classification
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Initial Source
Streptomyces albogriseolus
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thienodolin Related Classifications
HY-N16376 Related Classifications
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