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Spon2 - spondin 2, extracellular matrix protein Gene

Also Known as Mindin; Mspondin; M-spondin; 2310045I24Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 100689

Summary

Enables antigen binding activity and lipopolysaccharide binding activity. Acts upstream of or within several processes, including defense response to Other organism; opsonization; and positive regulation of cytokine production. Located in extracellular matrix and extracellular space. Orthologous to human SPON2 (spondin 2). [provided by Alliance of Genome Resources, Apr 2022]

Spon2 Products (1)

mRNA	Protein	Name
NM_133903.3	NP_598664.3	spondin-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables antigen binding	IDA IDA: Inferred from direct assay	14691481	MGI
enables antigen binding	IMP IMP: Inferred from mutant phenotype	14691481	MGI
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	14691481	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14691481	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	14691481	MGI
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within defense response to fungus	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within induction of bacterial agglutination	IDA IDA: Inferred from direct assay	14691481	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of interleukin-6 production	IDA IDA: Inferred from direct assay	14691481	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within mast cell mediated immunity	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within opsonization	IDA IDA: Inferred from direct assay	14691481	MGI
acts upstream of or within opsonization	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	14691481	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	14691481	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	14691481	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	14691481	MGI
acts upstream of tumor necrosis factor production	IDA IDA: Inferred from direct assay	14691481	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	14691481	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	14691481	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	14691481	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
spondin-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13699	SPON2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19239	Spon2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25728	Spon2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spon2	NCBI	NCBI:10417