CDH16 - cadherin 16 Gene
Species: Homo sapiens
About CDH16
Restricted expression toward kidney (RPKM 177.1).
Summary
This gene is a member of the Cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of Cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 Cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical Cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
CDH16 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001204744.2 | NP_001191673.1 | cadherin-16 isoform 2 precursor |
| NM_001204745.2 | NP_001191674.1 | cadherin-16 isoform 3 precursor |
| NM_001204746.2 | NP_001191675.1 | cadherin-16 isoform 4 precursor |
| NM_004062.4 | NP_004053.1 | cadherin-16 isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32814053 | GOA |
CDH16 Protein Structure
Cadherin: Cadherin domain (133 - 231)
Cadherin: Cadherin domain (267 - 324)
Cadherin: Cadherin domain (342 - 439)
Cadherin: Cadherin domain (457 - 555)
- 0
- 200
- 400
- 600
- 829 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cadherin-16 |
|
Recombinant CDH16 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P73507 | CDH16 Protein, Human (HEK293, His) | O75309/NP_004053.1 (K19-A786) | ≥ 95%, as determined by reducing SDS-PAGE. |
CDH16 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81731 | Cadherin 16 Antibody (YA1476) | WB, IHC-P, IP | Human, Mouse |
| HY-P85997 | Cadherin 16 Antibody (YA5689) | IHC-P, ICC/IF, ELISA | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Oncocytoma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Eosinophilic Variant Of Chromophobe Renal Cell Carcinoma |
|
|
| Renal Oncocytoma |
|
|
| Multilocular Clear Cell Renal Cell Carcinoma |
|
|
| Fetal Adenoma |
|
|
| Epithelial Predominant Wilms' Tumor |
|
|
| Kidney Benign Neoplasm |
|
|
| Collecting Duct Carcinoma |
|
|
| Renal Adenoma |
|
|
| Birt-Hogg-Dube Syndrome |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS02327 | CDH17 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS02326 | CDH16 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS17905 | Cdh16 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS24374 | Cdh16 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | CDH16 | VGNC | VGNC:60674 |
| Macaca mulatta | CDH16 | VGNC | VGNC:70809 |
| Rattus norvegicus | CDH16 | RGD | RGD:1311638 |
| Mus musculus | CDH16 | MGD | MGI:106671 |
| Canis familiaris | CDH16 | VGNC | VGNC:39024 |
| Bos taurus | CDH16 | VGNC | VGNC:27095 |
| Others | CDH16 | NCBI |
Compound Screening Libraries
Virtual Screening
Customize Your Library
Drug Screening Service