PAK1 - p21 (RAC1) activated kinase 1 Gene
Species: Macaca fascicularis
Gene Type: protein coding
Gene ID: 101866132
About PAK1
Primary_assembly 14: 68,021,935-68,406,551 reverse strand.Macaca_fascicularis_6.0:CM021952.1
This gene has 8 transcripts (splice variants), 269 orthologues and 5 paralogues.
PAK1 Products (15)
| mRNA | Protein | Name |
|---|---|---|
| XM_005579167.3 | XP_005579224.1 | serine/threonine-protein kinase PAK 1 isoform X4 |
| XM_005579163.3 | XP_005579220.1 | serine/threonine-protein kinase PAK 1 isoform X1 |
| XM_005579166.3 | XP_005579223.1 | serine/threonine-protein kinase PAK 1 isoform X3 |
| XM_045371243.1 | XP_045227178.1 | serine/threonine-protein kinase PAK 1 isoform X4 |
| XM_045371245.1 | XP_045227180.1 | serine/threonine-protein kinase PAK 1 isoform X4 |
| XM_005579165.3 | XP_005579222.1 | serine/threonine-protein kinase PAK 1 isoform X1 |
| XM_005579169.3 | XP_005579226.1 | serine/threonine-protein kinase PAK 1 isoform X5 |
| XM_005579168.3 | XP_005579225.1 | serine/threonine-protein kinase PAK 1 isoform X4 |
| XM_015435526.2 | XP_015291012.1 | serine/threonine-protein kinase PAK 1 isoform X2 |
| XM_015435524.2 | XP_015291010.1 | serine/threonine-protein kinase PAK 1 isoform X1 |
| XM_005579164.3 | XP_005579221.1 | serine/threonine-protein kinase PAK 1 isoform X1 |
| XM_045371247.1 | XP_045227182.1 | serine/threonine-protein kinase PAK 1 isoform X6 |
| XM_045371242.1 | XP_045227177.1 | serine/threonine-protein kinase PAK 1 isoform X1 |
| XM_045371246.1 | XP_045227181.1 | serine/threonine-protein kinase PAK 1 isoform X6 |
| XM_015435525.2 | XP_015291011.1 | serine/threonine-protein kinase PAK 1 isoform X1 |
PAK1 Protein Structure
PBD
PBD: pfam00786 (73 - 131)
STKc_PAK1
STKc_PAK1: cd06654 (269 - 564)
- 0
- 100
- 200
- 300
- 400
- 500
- 566 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein kinase PAK 1 |
|
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
Bioactive Molecules
(3)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-12005 | Fingolimod hydrochloride | Activator | 99.94% | Yes |
| HY-15027 | 5-Aminosalicylic Acid | Inhibitor | 99.97% | Unkown |
| HY-11063 | Fingolimod | Activator | 99.97% | Yes |
Clinical Phase
Bioactive Molecules
(3)
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-13007 | PF-3758309 | Inhibitor | 99.79% | Phase 1 |
| HY-13007B | PF-3758309 dihydrochloride | Inhibitor | / | Phase 1 |
| HY-13007A | PF-3758309 hydrochloride | Inhibitor | / | Phase 1 |
Pre-clinical Phase
Bioactive Molecules
(22)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-15663 | IPA-3 | Inhibitor | 99.39% | Unkown |
| HY-15542A | FRAX597 | Inhibitor | 99.36% | Unkown |
| HY-15542B | FRAX486 | Inhibitor | 98.10% | Unkown |
| HY-19635 | G-5555 | Inhibitor | 99.88% | Unkown |
| HY-19538 | FRAX1036 | Inhibitor | 98.88% | Unkown |
| HY-120940 | AZ13705339 | Inhibitor | 98.57% | Unkown |
| HY-19635A | G-5555 hydrochloride | Inhibitor | 98.26% | Unkown |
| HY-131043 | NVS-PAK1-C | Inhibitor | 99.2% | Unkown |
| HY-120940A | AZ13705339 hemihydrate | Inhibitor | 99.77% | Unkown |
| HY-182357 | PAK1-IN-3 | Inhibitor | / | Unkown |
| HY-146681 | PAK1-IN-1 | Inhibitor | / | Unkown |
| HY-164534 | SIK2/3-IN-2 | Inhibitor | / | Unkown |
| HY-116917 | G-9791 | Inhibitor | / | Unkown |
| HY-146786 | ZMF-10 | Inhibitor | / | Unkown |
| HY-159897 | PAK4-IN-5 | Inhibitor | / | Unkown |
| HY-146783 | ZINC194100678 | Inhibitor | / | Unkown |
| HY-184145 | AKT1-IN-13 | Inhibitor | / | Unkown |
| HY-119216 | AZ13711265 | Inhibitor | / | Unkown |
| HY-110085 | 2,2′-Dihydroxy-6,6′-dinaphthyl disulfide | Inhibitor | 98.49% | Unkown |
| HY-131265 | Mesalamine impurity P | Inhibitor | / | Unkown |
| HY-176539 | PAK1-IN-2 | Inhibitor | / | Unkown |
| HY-164374 | AK963/40708899 | Inhibitor | / | Unkown |
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