Rrn3 - RRN3 RNA polymerase I transcription factor homolog (yeast) Gene

Also Known as Tif1a; TIF-1A; E130302O19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 106298

Summary

Enables RNA polymerase binding activity. Acts upstream of or within several processes, including negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; regulation of transcription, DNA-templated; and transcription initiation from RNA polymerase I promoter. Predicted to be located in nucleolus. Predicted to be active in nucleus. Used to study Parkinson's disease. Orthologous to several human genes including RRN3 (RRN3 homolog, RNA polymerase I transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Rrn3 Products (1)

mRNA Protein Name
NM_001039521.1 NP_001034610.1 RNA polymerase I-specific transcription initiation factor RRN3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase binding IDA
IDA: Inferred from direct assay
8413268 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA-templated transcription initiation IDA
IDA: Inferred from direct assay
8413268 MGI
acts upstream of or within cytoplasm organization IMP
IMP: Inferred from mutant phenotype
15989966 MGI
acts upstream of or within fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
15989966 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
15989966 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15989966 MGI
acts upstream of intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
15989966 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
15989966 MGI
acts upstream of or within nucleolus organization IMP
IMP: Inferred from mutant phenotype
15989966 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8413268 MGI
acts upstream of or within regulation of DNA-templated transcription initiation IDA
IDA: Inferred from direct assay
8413268 MGI
acts upstream of or within ribosome biogenesis IMP
IMP: Inferred from mutant phenotype
15989966 MGI
acts upstream of or within transcription initiation at RNA polymerase I promoter IMP
IMP: Inferred from mutant phenotype
15989966 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA polymerase I-specific transcription initiation factor RRN3

  • transcription initiation factor TIF-IA

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12288 RRN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18787 Rrn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25276 Rrn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rrn3 NCBI NCBI:54700