RRN3 - RRN3 homolog, RNA polymerase I transcription factor Gene

Also Known as TIFIA; A-270G1.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54700

About RRN3

Cytogenetic location: 16p13.11 Genomic coordinates (GRCh38): 16:15,060,022-15,094,335 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 208 orthologues. Ubiquitous expression in bone marrow (RPKM 15.3), thyroid (RPKM 14.8) and 25 other tissues.

Summary

Enables RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation from RNA polymerase I promoter. Predicted to act upstream of or within several processes, including DNA-templated transcription, initiation; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of transcription, DNA-templated. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

RRN3 Products (2)

mRNA Protein Name
NM_001301064.1 NP_001287993.1 RNA polymerase I-specific transcription initiation factor RRN3 isoform 2
NM_018427.5 NP_060897.3 RNA polymerase I-specific transcription initiation factor RRN3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase I core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22368283 GOA
enables RNA polymerase I general transcription initiation factor activity IDA
IDA: Inferred from direct assay
11250903 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11250903 GOA
Biological Process GO Annotation Evidence References Source
involved in transcription initiation at RNA polymerase I promoter IDA
IDA: Inferred from direct assay
11250903 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
28334682 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRN3 Protein Structure

RRN3

RRN3: RNA polymerase I specific transcription initiation factor RRN3 (54 - 587)

  • 0
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  • 600
  • 651 a.a.
Protein Preferred Names Protein Names

RNA polymerase I-specific transcription initiation factor RRN3

  • RRN3 RNA polymerase I transcription factor homolog

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12288 RRN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18787 Rrn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25276 Rrn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RRN3 RGD RGD:1305001
Mus musculus RRN3 MGD MGI:1925255
Others RRN3 NCBI