CGREF1 - cell growth regulator with EF-hand domain 1 Gene

Also Known as CGR11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10669

About CGREF1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,099,353-27,119,128 (from NCBI)

This gene has 8 transcripts (splice variants), 90 orthologues and 1 paralogue. Broad expression in kidney (RPKM 22.2), small intestine (RPKM 16.6) and 14 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

CGREF1 Products (4)

mRNA Protein Name
NM_001166239.2 NP_001159711.1 cell growth regulator with EF hand domain protein 1 isoform a precursor
NM_001166240.2 NP_001159712.1 cell growth regulator with EF hand domain protein 1 isoform b precursor
NM_001301324.2 NP_001288253.1 cell growth regulator with EF hand domain protein 1 isoform d
NM_006569.6 NP_006560.3 cell growth regulator with EF hand domain protein 1 isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CGREF1 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (75 - 141)

  • 0
  • 100
  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

cell growth regulator with EF hand domain protein 1

  • cell growth regulatory gene 11 protein

CGREF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CGREF1 Q99674 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
CGREF1 Q99674 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
CGREF1 Q99674 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CGREF1 Proteins

Cat. No. Product Name Accession Purity
HY-P70107 CGREF1 Protein, Human (HEK293, His) A0A4W8VYG7 (A20-I301) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02587 CGREF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18855 Cgref1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25347 Cgref1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CGREF1 VGNC VGNC:80063
Macaca mulatta CGREF1 VGNC VGNC:106140
Canis familiaris CGREF1 VGNC VGNC:106594
Rattus norvegicus CGREF1 RGD RGD:620801
Mus musculus CGREF1 MGD MGI:1915817
Others CGREF1 NCBI