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CNPY3 - canopy FGF signaling regulator 3 Gene

Also Known as CAG4A; DEE60; ERDA5; TNRC5; EIEE60; PRAT4A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10695

About CNPY3

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,928,002-42,939,294 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 21.7), bone marrow (RPKM 19.8) and 25 other tissues.

Summary

This gene encodes a protein that binds members of the Toll-like Receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrough transcription occurs between this locus and the downstream GNMT (glycine N-methyltransferase) gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]

CNPY3 Products (5)

mRNA	Protein	Name
NM_001318842.1	NP_001305771.1	protein canopy homolog 3 isoform 3 precursor
NM_001318845.1	NP_001305774.1	protein canopy homolog 3 isoform 2
NM_001318847.2	NP_001305776.1	protein canopy homolog 3 isoform 5 precursor
NM_001318848.2	NP_001305777.1	protein canopy homolog 3 isoform 6 precursor
NM_006586.5	NP_006577.2	protein canopy homolog 3 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNPY3 Protein Structure

DUF3456

0
100
200
278 a.a.

Protein Preferred Names	Protein Names
protein canopy homolog 3	CAG repeat containing

CNPY3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CNPY3	Q9BT09	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	CNPY3	Q9BT09	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	CNPY3	Q9BT09	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	CNPY3	Q9BT09	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	CNPY3	Q9BT09	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	CNPY3	Q9BT09	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	CNPY3	Q9BT09	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	CNPY3	Q9BT09	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	CNPY3	Q9BT09	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	CNPY3	Q9BT09	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	CNPY3	Q9BT09	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	CNPY3	Q9BT09	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	CNPY3	Q9BT09	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	CNPY3	Q9BT09	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	CNPY3	Q9BT09	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	CNPY3	Q9BT09	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	CNPY3	Q9BT09	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	CNPY3	Q9BT09	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	CNPY3	Q9BT09	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	CNPY3	Q9BT09	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	CNPY3	Q9BT09	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	CNPY3	Q9BT09	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	CNPY3	Q9BT09	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	CNPY3	Q9BT09	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CNPY3	Q9BT09	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	CNPY3	Q9BT09	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CNPY3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75680	CNPY3/PRAT4A Protein, Human (HEK293, Fc)	Q9BT09-1 (G31-P274)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 60	DEE60 Epileptic Encephalopathy, Early Infantile, 60 Eiee60 Developmental And Epileptic Encephalopathy, 60 Early Infantile Epileptic Encephalopathy 60
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic
Developmental And Epileptic Encephalopathy 27	DEE27 Epileptic Encephalopathy, Early Infantile, 27 Eiee27 Developmental And Epileptic Encephalopathy, 27 Early Infantile Epileptic Encephalopathy 27 Encephalopathy, Developmental And Epileptic, Type 27
Developmental And Epileptic Encephalopathy 11	Epileptic Encephalopathy, Early Infantile, 11 DEE11 Eiee11 Developmental And Epileptic Encephalopathy, 11 Early Infantile Epileptic Encephalopathy 11 Encephalopathy, Developmental And Epileptic, Type 11
Cataract 34, Multiple Types	Cataract, Autosomal Recessive Congenital 3 Cataract 34 Multiple Types CTRCT34 Catc3 Cataract 34, Multiple Types, With Or Without Microcornea Autosomal Recessive Congenital Cataract 3 Cataract 34 Multiple Types With Or Without Microcornea Cataract, Multiple Types, Type 34
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02912	CNPY3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18655	Cnpy3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25141	Cnpy3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CNPY3	MGD	MGI:1919279
Bos taurus	CNPY3	VGNC	VGNC:27527
Rattus norvegicus	CNPY3	RGD	RGD:1597709
Macaca mulatta	CNPY3	VGNC	VGNC:81055
Felis catus	CNPY3	VGNC	VGNC:61032
Canis familiaris	CNPY3	VGNC	VGNC:39424
Others	CNPY3	NCBI