2. Gene
  3. UGT2A1 - UDP glucuronosyltransferase family 2 member A1 complex locus Gene

UGT2A1 - UDP glucuronosyltransferase family 2 member A1 complex locus Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as UDPGT2A1

Gene ID: 10941 | Gene type: protein coding

About UGT2A1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,588,417-69,653,247 (from NCBI)

This gene has 7 transcripts (splice variants), 1196 orthologues and 21 paralogues. Biased expression in kidney (RPKM 2.3), liver (RPKM 2.2) and 1 other tissue.

Summary

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded Enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 Infection. [provided by RefSeq, Jan 2022]

UGT2A1 Products(5)

mRNA Protein Name
NM_001252274.3 NP_001239203.2 UDP-glucuronosyltransferase 2A1 isoform 2 precursor
NM_001252275.3 NP_001239204.2 UDP-glucuronosyltransferase 2A1 isoform 3 precursor
NM_001301239.2 NP_001288168.1 UDP-glucuronosyltransferase 2A1 isoform 4 precursor
NM_001389565.1 NP_001376494.1 UDP-glucuronosyltransferase 2A1 isoform 5 precursor
NM_006798.5 NP_006789.3 UDP-glucuronosyltransferase 2A1 isoform 1 precursor

UGT2A1 Protein Structure

UDPGT

UDPGT: UDP-glucoronosyl and UDP-glucosyl transferase (21 - 524)

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  • 527 a.a.
Protein Preferred Names Protein Names

UDP-glucuronosyltransferase 2A1

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15434 UGT2A1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UGT2A1 MGD MGI:2149905
Rattus norvegicus UGT2A1 RGD RGD:69432