Fgb - fibrinogen beta chain Gene

Also Known as 2510049G14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110135

Summary

This gene encodes the beta subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded preproprotein is proteolytically processed by Thrombin to release an N-terminal fibrinopeptide during the conversion of fibrinogen to insoluble fibrin polymer. The encoded protein interacts with the amyloid beta peptide to form fibrin clots of abnormal structure, and may play an important role in Alzheimer's disease. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. [provided by RefSeq, Nov 2015]

Fgb Products (1)

mRNA Protein Name
NM_181849.3 NP_862897.1 fibrinogen beta chain preproprotein

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence Références Source
located in cell cortex IDA
IDA: Inferred from direct assay
15914557 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16452087 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16452087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibrinogen beta chain

  • fibrinogen, B beta polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS19861 Fgb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04879 FGB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26361 Fgb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgb NCBI NCBI:2244