GPR45 - G protein-coupled receptor 45 Gene

Also Known as PSP24; PSP24A; PSP24(ALPHA)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11250

About GPR45

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:105,241,743-105,243,467 (from NCBI)

This gene has 1 transcript (splice variant), 172 orthologues, 3 paralogues and is associated with 1 phenotype.

Summary

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]

GPR45 Products (1)

mRNA Protein Name
NM_007227.3 NP_009158.3 probable G-protein coupled receptor 45

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR45 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (51 - 324)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 45

  • PSP24-1

GPR45 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GPR45 Q9Y5Y3 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra
GPR45 Q9Y5Y3 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Diversion Colitis
Vascular Parkinsonism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05716 GPR45 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22536 Gpr45 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29056 Gpr45 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPR45 VGNC VGNC:73137
Bos taurus GPR45 VGNC VGNC:29588
Rattus norvegicus GPR45 RGD RGD:1306253
Felis catus GPR45 VGNC VGNC:67430
Canis familiaris GPR45 VGNC VGNC:41436
Mus musculus GPR45 MGD MGI:2135882
Others GPR45 NCBI