GABARAP - GABA type A receptor-associated protein Gene

Also Known as MM46; ATG8A; GABARAP-a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11337

About GABARAP

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,240,008-7,242,449 (from NCBI)

This gene has 6 transcripts (splice variants), 133 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 212.0), ovary (RPKM 206.1) and 25 other tissues.

Summary

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the Cytoskeleton. [provided by RefSeq, Jul 2008]

GABARAP Products (1)

mRNA	Protein	Name
NM_007278.2	NP_009209.1	gamma-aminobutyric acid receptor-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GABA receptor binding	IPI IPI: Inferred from physical interaction	9892355	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	9892355	GOA
enables phosphatidylethanolamine binding	IDA IDA: Inferred from direct assay	15169837	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9892355	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25127057	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	15977068	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25684205	GOA
involved in positive regulation of protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	25684205	GOA
involved in regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	25684205	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in autophagosome	IDA IDA: Inferred from direct assay	19056683	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	15169837	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABARAP Protein Structure

Atg8

0
100
117 a.a.

Protein Preferred Names	Protein Names
gamma-aminobutyric acid receptor-associated protein	GABA(A) receptor-associated protein

GABARAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GABARAP	O95166	NEK9	Homo sapiens	Q8TD19	Pull Down	20562859
Intra	GABARAP	O95166	NEK9	Homo sapiens	Q8TD19	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	TBC1D15	Homo sapiens	Q8TC07	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	CALR	Homo sapiens	P27797	X-Ray Diffraction	19154346
Intra	GABARAP	O95166	CALR	Homo sapiens	P27797	NMR	19154346
Intra	GABARAP	O95166	CALR	Homo sapiens	P27797	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	FNBP1	Homo sapiens	Q96RU3	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	GABRG2	Homo sapiens	P18507-2	Y2H	9892355
Intra	GABARAP	O95166	GABRG2	Homo sapiens	P18507-2	Pull Down	9892355
Cross	GABARAP	O95166	Bnip3l	Mus musculus	Q9Z2F7	Pull Down	20010802
Intra	GABARAP	O95166	MIB1	Homo sapiens	Q86YT6	Pull Down	28712572
Intra	GABARAP	O95166	MIB1	Homo sapiens	Q86YT6	Anti Bait CoIP	28712572
Intra	GABARAP	O95166	KBTBD6	Homo sapiens	Q86V97	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	KBTBD6	Homo sapiens	Q86V97	Pull Down	25684205
Intra	GABARAP	O95166	DDX47	Homo sapiens	Q9H0S4	Anti Tag CoIP	15977068
Intra	GABARAP	O95166	DDX47	Homo sapiens	Q9H0S4	Y2H	15977068
Intra	GABARAP	O95166	FYCO1	Homo sapiens	Q9BQS8	Pull Down	20562859
Intra	GABARAP	O95166	DNAAF4	Homo sapiens	Q8WXU2	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	FNIP1	Homo sapiens	Q8TF40	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	TECPR2	Homo sapiens	O15040	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	NSMAF	Homo sapiens	Q92636	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	STBD1	Homo sapiens	O95210	Pull Down	20562859
Intra	GABARAP	O95166	STBD1	Homo sapiens	O95210	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	SQSTM1	Homo sapiens	Q13501	Pull Down	20452972
Intra	GABARAP	O95166	SQSTM1	Homo sapiens	Q13501	Validated Y2H	32296183
Intra	GABARAP	O95166	SQSTM1	Homo sapiens	Q13501	TAP	24089205
Intra	GABARAP	O95166	SQSTM1	Homo sapiens	Q13501	FPS	33436498
Intra	GABARAP	O95166	SQSTM1	Homo sapiens	Q13501	Phage Display	37219487
Intra	GABARAP	O95166	NIPSNAP2	Homo sapiens	O75323	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	IPO5	Homo sapiens	O00410	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	HADHA	Homo sapiens	P40939	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	KBTBD7	Homo sapiens	Q8WVZ9	Pull Down	25684205
Intra	GABARAP	O95166	PLEKHM1	Homo sapiens	Q9Y4G2	Anti Tag CoIP	33452816
Intra	GABARAP	O95166	ATG4B	Homo sapiens	Q9Y4P1	Y2H Pooling	16169070
Intra	GABARAP	O95166	ATG4B	Homo sapiens	Q9Y4P1	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	NEDD4	Homo sapiens	P46934	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	PCM1	Homo sapiens	Q15154	TAP	24089205
Intra	GABARAP	O95166	PCM1	Homo sapiens	Q15154	Anti Bait CoIP	28712572
Intra	GABARAP	O95166	PCM1	Homo sapiens	Q15154	Anti Tag CoIP	28712572
Intra	GABARAP	O95166	PCM1	Homo sapiens	Q15154	Confocal	28712572
Intra	GABARAP	O95166	PCM1	Homo sapiens	Q15154	Pull Down	28712572
Intra	GABARAP	O95166	NBR1	Homo sapiens	Q14596	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	NBR1	Homo sapiens	Q14596	Pull Down	24879152
Intra	GABARAP	O95166	NBR1	Homo sapiens	Q14596	Pull Down	19250911
Intra	GABARAP	O95166	TSR2	Homo sapiens	Q969E8	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	TSR2	Homo sapiens	Q969E8	Validated Y2H	32296183
Intra	GABARAP	O95166	NCOA7	Homo sapiens	Q8NI08	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	SEC62	Homo sapiens	Q99442	Phage Display	37219487
Intra	GABARAP	O95166	ATG7	Homo sapiens	O95352	Comig Non-Denat Gel	16303767
Intra	GABARAP	O95166	ATG7	Homo sapiens	O95352	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	ATG3	Homo sapiens	Q9NT62	Anti Tag CoIP	20562859
Intra	GABARAP	O95166	ATG3	Homo sapiens	Q9NT62	Comig Non-Denat Gel	16303767
Intra	GABARAP	O95166	STK3	Homo sapiens	Q13188	Pull Down	20562859
Intra	GABARAP	O95166	TP53INP1	Homo sapiens	Q96A56	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GABARAP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70861	GABARAP Protein, Human (GST)	Q6IAW1 (M1-L117)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72639	GABARAP Protein, Human (His, Fc)	Q6IAW1 (M1-L117)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76942	GABARAP Protein, Human (His-MBP)	O95166 (M1-L117)	≥ 85%, as determined by reducing SDS-PAGE.

GABARAP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80136	GABARAP Antibody (YA423)	WB, IHC-P, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Stiff-Person Syndrome	SPS Stiff-Man Syndrome Stiff Man Syndrome Stiff Person Syndrome Moersch-Woltman Syndrome Sms Stiff-Trunk Syndrome Morsch Woltman Syndrome Stiff Person Syndrome And Related Disorders Stiff Person Spectrum Disorder Classic Stiff Person Syndrome Classic Sps Focal Stiff Limb Syndrome Focal Stiff-Person Syndrome Stiff Leg Syndrome Progressive Encephalomyelitis With Rigidity
Liver Carcinoma In Situ	Carcinoma In Situ Of Liver And Biliary System Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Retinitis Pigmentosa 84	RP84 Retinitis Pigmentosa, Type 84
Hereditary Sensory And Autonomic Neuropathy Type 1	Hereditary Sensory And Autonomic Neuropathy Type I Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome Hsan1e Hsan1 Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy Hsn1e Hsnie Hereditary Sensory Neuropathy Type Ie Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome Hereditary Sensory And Autonomic Neuropathy Type Ie Hereditary Sensory And Autonomic Neuropathy Type 1e Hereditary Sensory Neuropathy With Hearing Loss And Dementia Dnmt1-Complex Disorder Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss Hsn Ie Hereditary Sensory Autonomic Neuropathy, Type 1 Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16121	CAA-0225	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5964A	K1 peptide TFA	Ligand	98.59%	Unkown
HY-P11208C	mNLS-CPP-WSTF TFA	Inhibitor	96.20%	Unkown
HY-168347	TH152	Ligand	/	Unkown
HY-P11208	mNLS-CPP-WSTF	Inhibitor	/	Unkown
HY-P5964	K1 peptide	Ligand	/	Unkown
HY-RS05201	GABARAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17786	Gabarap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24253	Gabarap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GABARAP	RGD	RGD:61911
Mus musculus	GABARAP	MGD	MGI:1861742
Bos taurus	GABARAP	VGNC	VGNC:29185
Canis familiaris	GABARAP	VGNC	VGNC:41046
Felis catus	GABARAP	VGNC	VGNC:62414
Others	GABARAP	NCBI