TP53INP1 - tumor protein p53 inducible nuclear protein 1 Gene

Also Known as SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 94241

About TP53INP1

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,925,972-94,949,378 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 25.0), testis (RPKM 21.8) and 25 other tissues.

Summary

Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of autophagy; and positive regulation of transcription, DNA-templated. Located in autophagosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TP53INP1 Products (2)

mRNA Protein Name
NM_001135733.2 NP_001129205.1 tumor protein p53-inducible nuclear protein 1 isoform b
NM_033285.4 NP_150601.1 tumor protein p53-inducible nuclear protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22421968 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagic cell death IMP
IMP: Inferred from mutant phenotype
22421968 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22470510 GOA
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
22421968 GOA
Cellular Component GO Annotation Evidence References Source
located in autophagosome IDA
IDA: Inferred from direct assay
22421968 GOA
located in cytosol IDA
IDA: Inferred from direct assay
22470510 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22470510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53INP1 Protein Structure

DOR

DOR: DOR family (24 - 237)

  • 0
  • 100
  • 200
  • 240 a.a.
Protein Preferred Names Protein Names

tumor protein p53-inducible nuclear protein 1

  • p53-dependent damage-inducible nuclear protein 1

TP53INP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TP53INP1 Q96A56 MAP1LC3C Homo sapiens Q9BXW4
Y2H Prey Pooling
32296183
Intra
TP53INP1 Q96A56 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra
TP53INP1 Q96A56 MAP1LC3C Homo sapiens Q9BXW4
Y2H Array
32296183
Intra
TP53INP1 Q96A56 GABARAP Homo sapiens O95166
Y2H Prey Pooling
32296183
Intra
TP53INP1 Q96A56 GABARAP Homo sapiens O95166
Y2H Array
32296183
Intra
TP53INP1 Q96A56 GABARAPL2 Homo sapiens P60520
Y2H Prey Pooling
32296183
Intra
TP53INP1 Q96A56 GABARAPL2 Homo sapiens P60520
Y2H Array
32296183
Intra
TP53INP1 Q96A56 GABARAPL1 Homo sapiens Q9H0R8
Y2H Prey Pooling
32296183
Intra
TP53INP1 Q96A56 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Intra
TP53INP1 Q96A56 GABARAPL1 Homo sapiens Q9H0R8
Y2H Array
32296183
Intra
TP53INP1 Q96A56 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TP53INP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80259 p53 DINP1 Antibody (YA249) WB, ICC/IF Human, Mouse, Rat
HY-P810999 TP53INP1 Antibody WB, IHC-P Human, Monkey

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14920 TP53INP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28596 Tp53inp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TP53INP1 VGNC VGNC:66465
Bos taurus TP53INP1 VGNC VGNC:36236
Mus musculus TP53INP1 MGD MGI:1926609
Rattus norvegicus TP53INP1 RGD RGD:631423
Canis familiaris TP53INP1 VGNC VGNC:47725
Others TP53INP1 NCBI