2. Gene
  3. DDX47 - DEAD-box helicase 47 Gene

DDX47 - DEAD-box helicase 47 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RRP3; E4-DBP; HQ0256; MSTP162

Gene ID: 51202 | Gene type: protein coding

About DDX47

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:12,813,346-12,829,981 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 25.1), lymph node (RPKM 21.1) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DDX47 Products(2)

mRNA Protein Name
NM_016355.4 NP_057439.2 probable ATP-dependent RNA helicase DDX47 isoform 1
NM_201224.2 NP_957518.1 probable ATP-dependent RNA helicase DDX47 isoform 2

DDX47 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (48 - 215)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (282 - 358)

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  • 455 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03653 DDX47 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DDX47 VGNC VGNC:71664
Mus musculus DDX47 MGD MGI:1915005
Felis catus DDX47 VGNC VGNC:61410
Rattus norvegicus DDX47 RGD RGD:1310437
Bos taurus DDX47 VGNC VGNC:27970
Canis familiaris DDX47 VGNC VGNC:39860