SEC62 - SEC62 homolog, preprotein translocation factor Gene

Also Known as HTP1; TP-1; Dtrp1; TLOC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7095

About SEC62

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:169,966,807-169,998,373 (from NCBI)

This gene has 10 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in thyroid (RPKM 46.4), brain (RPKM 36.2) and 25 other tissues.

Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free Sec61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

SEC62 Products (1)

mRNA	Protein	Name
NM_003262.4	NP_003253.1	translocation protein SEC62

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within post-translational protein targeting to endoplasmic reticulum membrane	IMP IMP: Inferred from mutant phenotype	22375059	GOA
involved in post-translational protein targeting to membrane, translocation	IMP IMP: Inferred from mutant phenotype	29719251	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	22375059	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC62 Protein Structure

Sec62

0
100
200
300
399 a.a.

Protein Preferred Names	Protein Names
translocation protein SEC62	SEC62 preprotein translocation factor

SEC62 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SEC62	Q99442	GABARAP	Homo sapiens	O95166	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

SEC62 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87070	SEC62 Antibody (YA6763)	WB, IHC-P, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Hereditary Sensory And Autonomic Neuropathy Type 1	Hereditary Sensory And Autonomic Neuropathy Type I Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome Hsan1e Hsan1 Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy Hsn1e Hsnie Hereditary Sensory Neuropathy Type Ie Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome Hereditary Sensory And Autonomic Neuropathy Type Ie Hereditary Sensory And Autonomic Neuropathy Type 1e Hereditary Sensory Neuropathy With Hearing Loss And Dementia Dnmt1-Complex Disorder Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss Hsn Ie Hereditary Sensory Autonomic Neuropathy, Type 1 Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12624	SEC62 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SEC62	VGNC	VGNC:56236
Felis catus	SEC62	VGNC	VGNC:102838
Mus musculus	SEC62	MGD	MGI:1916526
Macaca mulatta	SEC62	VGNC	VGNC:84085
Rattus norvegicus	SEC62	RGD	RGD:1308862
Others	SEC62	NCBI