PGLYRP2 - peptidoglycan recognition protein 2 Gene

Also Known as tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114770

About PGLYRP2

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,468,645-15,479,501 (from NCBI)

This gene has 4 transcripts (splice variants), 274 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 52.9).

Summary

This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in Bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]

PGLYRP2 Products (2)

mRNA Protein Name
NM_001363546.1 NP_001350475.1 N-acetylmuramoyl-L-alanine amidase isoform 2 precursor
NM_052890.4 NP_443122.3 N-acetylmuramoyl-L-alanine amidase isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables N-acetylmuramoyl-L-alanine amidase activity IDA
IDA: Inferred from direct assay
14506276 GOA
enables peptidoglycan binding IDA
IDA: Inferred from direct assay
11461926 GOA
enables peptidoglycan immune receptor activity IDA
IDA: Inferred from direct assay
11461926 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
11461926 GOA
involved in detection of bacterium IDA
IDA: Inferred from direct assay
11461926 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGLYRP2 Protein Structure

Amidase_2

Amidase_2: N-acetylmuramoyl-L-alanine amidase (404 - 533)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 576 a.a.
Protein Preferred Names Protein Names

N-acetylmuramoyl-L-alanine amidase

  • peptidoglycan recognition protein L

Recombinant PGLYRP2 Proteins

Cat. No. Product Name Accession Purity
HY-P71844 PGLYRP2/PGRP-L Protein, Human (P.pastoris, His) Q96PD5-1 (S22-Q576) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cicatricial Entropion
Febrile Seizures, Familial, 4

  • FEB4

  • Convulsions, Familial Febrile, 4

  • Familial Febrile Seizures 4

  • Familial Febrile Convulsions 4
Meester-Loeys Syndrome

  • MRLS
Familial Febrile Seizures

  • Familial Febrile Convulsions

  • Feb

  • Febrile Seizures, Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10388 PGLYRP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20639 Pglyrp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27149 Pglyrp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PGLYRP2 VGNC VGNC:75887
Canis familiaris PGLYRP2 VGNC VGNC:44462
Mus musculus PGLYRP2 MGD MGI:1928099
Bos taurus PGLYRP2 VGNC VGNC:32792
Rattus norvegicus PGLYRP2 RGD RGD:1359183
Felis catus PGLYRP2 VGNC VGNC:64123
Others PGLYRP2 NCBI