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PGLYRP2/PGRP-L Protein, Human (P.pastoris, His)

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The PGLYRP2/PGRP-L protein is thought to act as a scavenger and may degrade bioactive peptidoglycan (PGN) into inactive fragments. Unlike direct bacteriolytic activity, PGLYRP2/PGRP-L appears to be primarily involved in modifying PGN structure, possibly as part of the host's defense against bacterial infection. PGLYRP2/PGRP-L Protein, Human (P.pastoris, His) is the recombinant human-derived PGLYRP2/PGRP-L protein, expressed by P. pastoris , with N-6*His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: P. pastoris
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • PGLYRP2/PGRP-L Protein, Human (P.pastoris, His) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

The PGLYRP2/PGRP-L protein is thought to act as a scavenger and may degrade bioactive peptidoglycan (PGN) into inactive fragments. Unlike direct bacteriolytic activity, PGLYRP2/PGRP-L appears to be primarily involved in modifying PGN structure, possibly as part of the host's defense against bacterial infection. PGLYRP2/PGRP-L Protein, Human (P.pastoris, His) is the recombinant human-derived PGLYRP2/PGRP-L protein, expressed by P. pastoris , with N-6*His labeled tag.

Background

PGLYRP2/PGRP-L Protein is postulated to function in a scavenger role, potentially contributing to the degradation of biologically active peptidoglycan (PGN) into biologically inactive fragments. Unlike direct bacteriolytic activities, PGLYRP2/PGRP-L seems to be primarily involved in modifying the structure of PGN, possibly as part of the host's defense mechanisms against bacterial infections. The precise molecular pathways through which PGLYRP2/PGRP-L exerts its scavenger function and its implications in immune responses warrant further investigation to unravel its specific contributions to the intricate interplay between host and microbial elements.

Verified Bioactivity

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Technical Parameters

  • Species Human
  • Source P. pastoris
  • Tag N-6*His
  • Accession

    Q96PD5-1 (S22-Q576)

  • Gene ID
    114770  [NCBI]
  • Molecular Construction
    • N-term
    • 6*His
    • PGLYRP2 (S22-Q576)
      Accession # Q96PD5-1
    • C-term
  • Protein Length

    Full Length of Isoform-1 Mature Protein

  • Synonyms

    PGLYRP2; Tagl-Beta; Peptidoglycan Recognition Protein 2; TagL; PGLYRPL; Peptidoglycan Recognition Protein Long; PGRP-L; Peptidoglycan Recognition Protein L Precursor; PGRPL; Peptidoglycan Recognition Protein-Like; N-Acetylmuramoyl-L-Alanine Amidase; Pepti

  • AA Sequence

    SLPLLMDSVIQALAELEQKVPAAKTRHTASAWLMSAPNSGPHNRLYHFLLGAWSLNATELDPCPLSPELLGLTKEVARHDVREGKEYGVVLAPDGSTVAVEPLLAGLEAGLQGRRVINLPLDSMAAPWETGDTFPDVVAIAPDVRATSSPGLRDGSPDVTTADIGANTPDATKGCPDVQASLPDAKAKSPPTMVDSLLAVTLAGNLGLTFLRGSQTQSHPDLGTEGCWDQLSAPRTFTLLDPKASLLTMAFLNGALDGVILGDYLSRTPEPRPSLSHLLSQYYGAGVARDPGFRSNFRRQNGAALTSASILAQQVWGTLVLLQRLEPVHLQLQCMSQEQLAQVAANATKEFTEAFLGCPAIHPRCRWGAAPYRGRPKLLQLPLGFLYVHHTYVPAPPCTDFTRCAANMRSMQRYHQDTQGWGDIGYSFVVGSDGYVYEGRGWHWVGAHTLGHNSRGFGVAIVGNYTAALPTEAALRTVRDTLPSCAVRAGLLRPDYALLGHRQLVRTDCPGDALFDLLRTWPHFTATVKPRPARSVSKRSRREPPPRTLPATDLQ

  • Predicted Molecular Mass

    62 kDa

  • Molecular Weight

    Approximately 72 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 90%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HC1, 0.5 M NaCl, 6% trehalose, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • PGLYRP2/PGRP-L Protein, Human (P.pastoris, His) Product Image