Fbn1 - fibrillin 1 Gene

Also Known as Tsk; Fib-1; B430209H23

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14118

Summary

This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Homozygous knockout mice for this gene exhibit impaired aortic development and early postnatal death, which was attributed to a deficiency in the fibrillin-1 protein. Mice with a hypomorphic allele of this gene exhibit impaired glucose homeostasis, likely due to a reduction in serum asprosin levels. [provided by RefSeq, Apr 2016]

Fbn1 Products (1)

mRNA	Protein	Name
NM_007993.2	NP_032019.2	fibrillin-1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hormone activity	IDA IDA: Inferred from direct assay	29106398	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19940141	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	17581616	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	16439805	MGI
acts upstream of or within immunoglobulin production	IMP IMP: Inferred from mutant phenotype	17581616	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	16439805	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	16439805	MGI
involved in negative regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	33705351	MGI
involved in negative regulation of insulin secretion	IDA IDA: Inferred from direct assay	30997682	MGI
involved in negative regulation of osteoclast development	IDA IDA: Inferred from direct assay	24039232	MGI
involved in negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	24039232	MGI
involved in positive regulation of appetite	IDA IDA: Inferred from direct assay	29106398	MGI
involved in sequestering of BMP in extracellular matrix	IMP IMP: Inferred from mutant phenotype	20855508	MGI
involved in sequestering of TGFbeta in extracellular matrix	IMP IMP: Inferred from mutant phenotype	20855508	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	17099216	MGI
is active in extracellular space	IDA IDA: Inferred from direct assay	29106398	MGI
located in microfibril	IDA IDA: Inferred from direct assay	26405179	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fibrillin-1	tight skin

Recombinant Fbn1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7811	Fibrillin-1/Asprosin Protein, Mouse (HEK293, His)	Q61554 (S2734-H2873)	≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04776	FBN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17804	Fbn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24272	Fbn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fbn1	NCBI	NCBI:2200