Ostm1 - osteopetrosis associated transmembrane protein 1 Gene

Also Known as gl; HSPC019; 1200002H13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14628

Summary

Acts upstream of or within osteoclast differentiation. Located in cytosol. Is expressed in several structures, including alimentary system; hemolymphoid system gland; nervous system; skeleton; and skin. Used to study autosomal recessive osteopetrosis 5. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 5. Orthologous to human OSTM1 (osteoclastogenesis associated transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ostm1 Products (1)

mRNA Protein Name
NM_172416.3 NP_766004.1 osteopetrosis-associated transmembrane protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16525474 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
12627228 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
12627228 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

osteopetrosis-associated transmembrane protein 1

  • chloride channel 7 beta subunit

  • grey lethal osteopetrosis

Ostm1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ostm1 Q8BGT0 Clcn7 Mus musculus O70496
Anti Bait CoIP
16525474
Intra
Ostm1 Q8BGT0 Clcn7 Mus musculus O70496
IF
16525474
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ostm1 Proteins

Cat. No. Product Name Accession Purity
HY-P77117 OSTM1 Protein, Mouse (HEK293, His) Q8BGT0 (A35-S288) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09857 OSTM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18673 Ostm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25159 Ostm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ostm1 NCBI NCBI:28962