CST5 - cystatin D Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1473

About CST5

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,875,934-23,879,748 (from NCBI)

This gene has 1 transcript (splice variant), 122 orthologues and 11 paralogues. Restricted expression toward salivary gland (RPKM 368.3).

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008]

CST5 Products (1)

mRNA Protein Name
NM_001900.5 NP_001891.2 cystatin-D precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
8083219 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8083219 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
8083219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CST5 Protein Structure

Cystatin

Cystatin: Cystatin domain (32 - 128)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

cystatin-D

  • cystatin 5

Recombinant CST5 Proteins

Cat. No. Product Name Accession Purity
HY-P70020 Cystatin D/CST5 Protein, Human (HEK293, His) P28325 (G21-V142) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cerebral Amyloid Angiopathy, Cst3-Related

  • Cerebral Amyloid Angiopathy

  • Hereditary Cerebral Hemorrhage With Amyloidosis

  • Hchwa

  • Hereditary Cystatin C Amyloid Angiopathy

  • Cerebral Amyloid Angiopathy, Familial

  • Amyloidosis, Cerebroarterial, Icelandic Type

  • Amyloidosis Vi

  • Cerebral Hemorrhage, Hereditary, With Amyloidosis

  • Cst3-Related Cerebral Amyloid Angiopathy

  • Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

  • Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

  • Caa, Familial

  • Cerebral Amyloid Angiopathy, Genetic

  • Acys Amyloidosis

  • Cst3-Related Amyloidosis

  • Cystatin Amyloidosis

  • Hchwa, Icelandic Type

  • Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

  • Amyloidosis 6

  • AMYL6

  • Acys

  • Caa

  • Cerebral Amyloid Angiopathy Cst3-Related

  • Cerebroarterial Amyloidosis Icelandic Type

  • Cystatin C Amyloidosis

  • Hccaa

  • Hchwai

  • Hchwa-I

  • Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

  • Cerebral Amyloid Angiopathy Familial

  • Angiopathy, Amyloid, Cerebral, Cst3-Related

  • Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

  • Familial Cerebral Amyloid Angiopathy

  • Cerebral Amyloid Angiopathy, Hereditary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03266 CST5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19590 Cst5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26087 Cst5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CST5 RGD RGD:1310978
Mus musculus CST5 MGD MGI:1930004
Macaca mulatta CST5 VGNC VGNC:71530
Others CST5 NCBI