CNKSR3 - CNKSR family member 3 Gene

Also Known as CNK3; MAGI1; CNK3/IPCEF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 154043

About CNKSR3

Cytogenetic location: 6q25.2 Genomic coordinates (GRCh38): 6:154,387,515-154,510,685 (from NCBI)

This gene has 5 transcripts (splice variants), 103 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 6.3), kidney (RPKM 5.3) and 24 other tissues.

Summary

Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; and positive regulation of sodium ion transport. Predicted to act upstream of or within positive regulation of sodium ion transmembrane transporter activity. Predicted to be located in apical plasma membrane and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CNKSR3 Products (5)

mRNA Protein Name
NM_001368116.1 NP_001355045.1 connector enhancer of kinase suppressor of ras 3 isoform 1
NM_001368117.1 NP_001355046.1 connector enhancer of kinase suppressor of ras 3 isoform 3
NM_001368118.1 NP_001355047.1 connector enhancer of kinase suppressor of ras 3 isoform 4
NM_001368119.1 NP_001355048.1 connector enhancer of kinase suppressor of ras 3 isoform 5
NM_173515.4 NP_775786.2 connector enhancer of kinase suppressor of ras 3 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22085542 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNKSR3 Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (6 - 67)

CRIC_ras_sig

CRIC_ras_sig: Connector enhancer of kinase suppressor of ras (80 - 173)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (217 - 286)

DUF1170

DUF1170: Protein of unknown function (DUF1170) (330 - 546)

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  • 500
  • 555 a.a.
Protein Preferred Names Protein Names

connector enhancer of kinase suppressor of ras 3

  • CNK homolog protein 3

CNKSR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNKSR3 Q6P9H4 JRK Homo sapiens O75564-2
Y2H Array
32296183
Intra
CNKSR3 Q6P9H4 JRK Homo sapiens O75564-2
Y2H Prey Pooling
32296183
Intra
CNKSR3 Q6P9H4 N4BP3 Homo sapiens O15049
Y2H Prey Pooling
32296183
Intra
CNKSR3 Q6P9H4 N4BP3 Homo sapiens O15049
Y2H Array
32296183
Intra
CNKSR3 Q6P9H4 NMI Homo sapiens Q13287
Y2H Prey Pooling
25416956
Intra
CNKSR3 Q6P9H4 NMI Homo sapiens Q13287
Validated Y2H
25416956
Intra
CNKSR3 Q6P9H4 NMI Homo sapiens Q13287
Y2H Array
25416956
Intra
CNKSR3 Q6P9H4 GPKOW Homo sapiens Q92917
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CNKSR3 Proteins

Cat. No. Product Name Accession Purity
HY-P76838 CNKSR3 Protein, Human (sf9, GST) Q6P9H4-1 (M1-V352) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02890 CNKSR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18856 Cnksr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25348 Cnksr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CNKSR3 VGNC VGNC:61019
Bos taurus CNKSR3 VGNC VGNC:27506
Mus musculus CNKSR3 MGD MGI:2674130
Rattus norvegicus CNKSR3 RGD RGD:1307544
Macaca mulatta CNKSR3 VGNC VGNC:104342
Others CNKSR3 NCBI