CFD - complement factor D Gene

Also Known as DF; ADN; PFD; ADIPSIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1675

About CFD

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:859,664-863,641 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 134 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in fat (RPKM 584.9), colon (RPKM 88.4) and 1 other tissue.

Summary

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates Insulin secretion in mice. Mutations in this gene underlie complement Factor D deficiency, which is associated with recurrent Bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]

CFD Products (2)

mRNA	Protein	Name
NM_001317335.2	NP_001304264.1	complement factor D isoform 2 precursor
NM_001928.4	NP_001919.2	complement factor D isoform 1 preproprotein

CFD Protein Structure

Trypsin

0
100
200
253 a.a.

Protein Preferred Names	Protein Names
complement factor D	C3 convertase activator

Recombinant CFD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7861	Complement Factor D/Adipsin Protein, Human (HEK293, His)	P00746 (I26-A253)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78545	Complement Factor D/Adipsin Protein, Human (HEK293, Fc)	P00746 (I26-A253)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P7861A	Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution)	P00746 (I26-A253)	≥ 95%, as determined by reducing SDS-PAGE.

CFD Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83046	Factor D Antibody (YA2791)	WB	Human
HY-P83046A	Factor D Antibody (YA2791)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Complement Factor D Deficiency	Recurrent Neisseria Infections Due To Factor D Deficiency CFDD Factor D Deficiency Deficiency, Complement Factor D
Meningococcemia
Myofibrillar Myopathy 10	MFM10 Myopathy, Myofibrillar, 10
Bacterial Meningitis	Meningitis, Bacterial Meningitis Bacterial Bm - [Bacterial Meningitis] Leptomeningitis Bacterial Pachymeningitis Bacterial Arachnoiditis Bacterial
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99298	Lampalizumab	Inhibitor	99.46%	Phase 3

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163684	Zoracopan	Inhibitor	99.85%	Unkown
HY-RS02559	CFD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10542	PIKFYVE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17155	Cfd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23605	Cfd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CFD	VGNC	VGNC:60826
Mus musculus	CFD	MGD	MGI:87931
Macaca mulatta	CFD	VGNC	VGNC:71115
Canis familiaris	CFD	VGNC	VGNC:39174
Bos taurus	CFD	VGNC	VGNC:97253
Rattus norvegicus	CFD	RGD	RGD:2498
Others	CFD	NCBI