Nfkbia - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Gene

Also Known as Nfkbi

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18035

Summary

Predicted to enable several functions, including NF-kappaB binding activity; nuclear localization sequence binding activity; and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; naris; and vibrissa follicle. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; hematologic Cancer (multiple); hepatitis B; hepatitis C; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbia Products (1)

mRNA Protein Name
NM_010907.2 NP_035037.2 NF-kappa-B inhibitor alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9223278 MGI
enables transcription regulator inhibitor activity IDA
IDA: Inferred from direct assay
7963540 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
17367755 MGI
acts upstream of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
15845452 MGI
acts upstream of or within cellular response to biotic stimulus IDA
IDA: Inferred from direct assay
23262141 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
24349514 MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within negative regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
15845452 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
7963540 MGI
acts upstream of or within negative regulation of myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
15845452 MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18505784 MGI
involved in positive regulation of transcription initiation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16322095 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
11799106 MGI
acts upstream of or within regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11799106 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21737317 MGI
acts upstream of or within response to exogenous dsRNA IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
12872135 MGI
acts upstream of or within response to muramyl dipeptide IDA
IDA: Inferred from direct assay
15692051 MGI
acts upstream of or within response to muscle stretch IDA
IDA: Inferred from direct assay
20442316 MGI
acts upstream of or within toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
18261938 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11799106 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11799106 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11799106 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NF-kappa-B inhibitor alpha

  • I(Kappa)B(alpha)

  • I-kappa-B-alpha

  • I-kappaBalpha

  • ikB-alpha

  • ikappaBalpha

  • nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha

  • nuclear factor of kappa light polyp gene enhancer in B-cell 1

Nfkbia Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nfkbia Q9Z1E3 Relb Mus musculus Q04863
Anti Bait CoIP
23086447
Intra
Nfkbia Q9Z1E3 Rela Mus musculus Q04207
Anti Bait CoIP
20634424
Intra
Nfkbia Q9Z1E3 Rela Mus musculus Q04207
Anti Bait CoIP
23850221
Intra
Nfkbia Q9Z1E3 Rela Mus musculus Q04207
Anti Bait CoIP
23086447
Intra
Nfkbia Q9Z1E3 Rela Mus musculus Q04207
Anti Bait CoIP
18401342
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09260 NFKBIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18565 Nfkbia Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25048 Nfkbia Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkbia NCBI NCBI:4792