DSG3 - desmoglein 3 Gene

Also Known as PVA; ABOLM; CDHF6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1830

About DSG3

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:31,447,741-31,478,702 (from NCBI)

This gene has 1 transcript (splice variant), 390 orthologues, 6 paralogues and is associated with 1 phenotype. Restricted expression toward esophagus (RPKM 200.1).

Summary

This gene encodes a member of the desmoglein family and Cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding Transmembrane Glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and Other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with Other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]

DSG3 Products (1)

mRNA	Protein	Name
NM_001944.3	NP_001935.2	desmoglein-3 preproprotein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11790773	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	30949721	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DSG3 Protein Structure

Cadherin

Cadherin_C

0
200
400
600
800
999 a.a.

Protein Preferred Names	Protein Names
desmoglein-3	130 kDa pemphigus vulgaris antigen

Recombinant DSG3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72174	DSG3 Protein, Human (His-SUMO)	P32926 (E50-R615)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700469	DSG3 Protein, Human (sf9, His)	P32926 (E50-R615)	≥ 95%, as determined by reducing SDS-PAGE.

DSG3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81470	Desmoglein 3 Antibody (YA1215)	WB	Human, Mouse, Rat
HY-P84263	Desmoglein 3 Antibody (YA3960)	WB, IHC-P, FC, ELISA	Human
HY-P84263A	Desmoglein 3 Antibody (YA3960)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Blistering, Acantholytic, Of Oral And Laryngeal Mucosa	ABOLM
Pemphigus
Pemphigus Vulgaris, Familial	Pemphigus Vulgaris Familial Pemphigus Vulgaris Pemphigus
Pemphigus Foliaceus	Pemphigus Foliaceous Pf Superficial Pemphigus
Herpetiform Pemphigus
Bullous Skin Disease	Skin Diseases Bullous Skin Diseases, Bullous
Bullous Pemphigoid	Benign Pemphigus Senile Dermatitis Herpetiformis Old Age Pemphigus Parapemphigus Pemphigoid Pemphigoid Bullous Pemphigoid, Bullous
Impetigo
Pemphigoid
Aphthous Stomatitis	Oral Ulcer Canker Sore Aphtha Aphthous Ulceration Oral Aphthae Oral Aphthous Ulcer Canker Sores Stomatitis, Aphthous Minor Oral Aphthous Ulceration
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Subcorneal Pustular Dermatosis	Subcorneal Pustular Dermatitis Sneddon-Wilkinson Disease Or Syndrome Pustulosis Subcornealis Sneddon-Wilkinson Disease Skin Diseases, Vesiculobullous Vesiculobullous Skin Disease
Lichen Planus	Lichen Ruber Planus Lichen, Ruber Planus Ruber Planus Lp - [Lichen Planus] Lichen Planus Of Wilson Wilson Lichen Ruber
Pemphigus Erythematosus	Seborrheic Pemphigus Senear-Usher Syndrome
Iga Pemphigus
Paraneoplastic Pemphigus
Bullous Impetigo
Ritter'S Disease	Staphylococcal Scalded Skin Syndrome Pemphigus Neonatorum Ritter Disease Dermatitis Exfoliativa Neonatorum Scalded Skin Syndrome Toxic Epidermal Necrolysis, Subcorneal Type Generalized Exfoliative Disease Ssss Ssss - [Staphylococcal Scalded Skin Syndrome]
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Autoimmune Disease Of Skin And Connective Tissue
Pemphigoid Gestationis	Herpes Gestationis Gestational Pemphigoid Gestational Herpes
Mucositis	Inflammatory Disease Of Mucous Membrane Gastrointestinal Mucositis
Pemphigus Gestationis
Pseudomembranous Conjunctivitis
Hidradenitis	Hydradenitis
Lichen Disease
Benign Chronic Pemphigus	Hailey-Hailey Disease Pemphigus, Benign Familial Familial Benign Pemphigus Benign Familial Pemphigus Familial Benign Chronic Pemphigus BCPM HHD Benign Chronic Familial Pemphigus Of Hailey-Hailey Pemphigus, Chronic, Benign
Tinea Corporis	Dermatophytosis Of The Body Dermatophytosis Of The Trunk
Cicatricial Pemphigoid	Mucous Membrane Pemphigoid Ocular Pemphigoid Benign Mucous Membrane Pemphigoid Benign Mucous Membrane Pemphigoid With Ocular Involvement Benign Mucosal Pemphigoid Pemphigoid, Benign Mucous Membrane Cicatricial Pemphigoid With Ocular Involvement Ocular Pemphigus Cicatricial Pemphigoid Disease Mucosal Pemphigoid Mucosynechial Pemphigoid Pemphigoid Cicatricial Cicatricial Pemphigoid Involving The Eye Ocular Cicatricial Pemphigoid
Darier-White Disease	Keratosis Follicularis Darier Disease Darier'S Disease DAR DD Darier White Disease Darier Disease Acral Hemorrhagic Type Darier Disease Segmental Darier Disease, Acral Hemorrhagic Type Darier Disease, Segmental
Adenoid Squamous Cell Carcinoma	Acantholytic Squamous Cell Carcinoma Adenocarcinoma With Squamous Metaplasia Adenoacanthoma Pseudoglandular Squamous Carcinoma
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Integumentary System Disease
Familial Woolly Hair Syndrome	Wooly Hair Familial Wooly Hair Syndrome Hereditary Woolly Hair Syndrome Hereditary Wooly Hair Syndrome Woolly Hair Syndrome With Woolly Hair Wooly Hair Syndrome
Autoimmune Disease Of Musculoskeletal System
Palmoplantar Keratoderma, Nonepidermolytic	Nonepidermolytic Palmoplantar Keratoderma NEPPK Tylosis Unna-Thost Syndrome Keratoderma, Palmoplantar, Diffuse Ppkne Keratoderma, Nonepidermolytic Palmoplantar Diffuse Nonepidermolytic Palmomplantar Keratoderma Thost-Unna Syndrome Non-Epidermolytic Palmoplantar Keratoderma Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type Diffuse Palmoplantar Keratoderma, Bothnian Type Krt1-Related Diffuse Nonepidermolytic Keratoderma Krt1-Related Diffuse Neppk Keratoderma, Palmoplantar, Non-Epidermolytic Nonepidermolytic Unna-Thost Disease Non-Epidermolytic Unna-Thost Disease Keratoderma, Palmoplantar, Nonepidermolytic Hyperkeratosis
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04023	DSG3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17585	Dsg3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24045	Dsg3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990403	Anti-DSG3 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DSG3	MGD	MGI:99499
Bos taurus	DSG3	VGNC	VGNC:28222
Canis familiaris	DSG3	VGNC	VGNC:40107
Macaca mulatta	DSG3	VGNC	VGNC:72003
Rattus norvegicus	DSG3	RGD	RGD:1592103
Others	DSG3	NCBI