2. Gene
  3. DTYMK - deoxythymidylate kinase Gene

DTYMK - deoxythymidylate kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CDC8; TMPK; TYMK; CONPM; PP3731

Gene ID: 1841 | Gene type: protein coding

About DTYMK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,675,747-241,686,815 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 9.1), lymph node (RPKM 8.0) and 25 other tissues.

Summary

Enables thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to act upstream of or within cellular response to growth factor stimulus and nucleotide biosynthetic process. Predicted to be located in mitochondrial intermembrane space and mitochondrial matrix. Predicted to be active in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DTYMK Products(6)

mRNA Protein Name
NM_001165031.2 NP_001158503.1 thymidylate kinase isoform 2
NM_001320902.2 NP_001307831.1 thymidylate kinase isoform 3
NM_001320903.2 NP_001307832.1 thymidylate kinase isoform 4
NM_001320904.2 NP_001307833.1 thymidylate kinase isoform 5
NM_001320905.2 NP_001307834.1 thymidylate kinase isoform 6
NM_012145.4 NP_036277.2 thymidylate kinase isoform 1

DTYMK Protein Structure

Thymidylate_kin

Thymidylate_kin: Thymidylate kinase (11 - 191)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

thymidylate kinase

dTMP kinase

Recombinant DTYMK Proteins

Cat. No. Product Name Accession Purity
HY-P70012 Thymidylate Protein, Human (HEK293, His) P23919 (M1-K212) ≥95%

Related Diseases

Diseases Alias
Neurodegeneration, Childhood-Onset, With Progressive Microcephaly

CONPM
Developmental And Epileptic Encephalopathy 50

DEE50

Epileptic Encephalopathy, Early Infantile, 50

Eiee50

Developmental And Epileptic Encephalopathy, 50

Congenital Disorder Of Glycosylation, Type Iz, Formerly

Cdg1z, Formerly

Carbohydrate Deficient Glycoprotein Syndrome Type Iz

Cdg Syndrome Type Iz

Cdg-Iz

Congenital Disorder Of Glycosylation Type 1z

Early Infantile Epileptic Encephalopathy 50

Cdg1z

Congenital Disorder Of Glycosylation 1z

Encephalopathy, Epileptic, Early Infantile,, Type 50
Submandibular Adenitis

Submandibular Lymphadenitis
Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB
Disease By Infectious Agent

Infectious Disease

Infectious Diseases
Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04043 DTYMK Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DTYMK VGNC VGNC:28240
Mus musculus DTYMK MGD MGI:108396
Felis catus DTYMK VGNC VGNC:61652
Macaca mulatta DTYMK VGNC VGNC:72008
Canis familiaris DTYMK VGNC VGNC:59076
Rattus norvegicus DTYMK RGD RGD:1309614
Others DTYMK NCBI