DTYMK - deoxythymidylate kinase Gene

Also Known as CDC8; TMPK; TYMK; CONPM; PP3731

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1841

About DTYMK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,675,747-241,686,815 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 9.1), lymph node (RPKM 8.0) and 25 other tissues.

Summary

Enables thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to act upstream of or within cellular response to growth factor stimulus and nucleotide biosynthetic process. Predicted to be located in mitochondrial intermembrane space and mitochondrial matrix. Predicted to be active in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DTYMK Products (6)

mRNA	Protein	Name
NM_001165031.2	NP_001158503.1	thymidylate kinase isoform 2
NM_001320902.2	NP_001307831.1	thymidylate kinase isoform 3
NM_001320903.2	NP_001307832.1	thymidylate kinase isoform 4
NM_001320904.2	NP_001307833.1	thymidylate kinase isoform 5
NM_001320905.2	NP_001307834.1	thymidylate kinase isoform 6
NM_012145.4	NP_036277.2	thymidylate kinase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12614151	GOA
enables thymidylate kinase activity	IDA IDA: Inferred from direct assay	8845311	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dTDP biosynthetic process	IDA IDA: Inferred from direct assay	12614151	GOA
involved in thymidine biosynthetic process	IDA IDA: Inferred from direct assay	12614151	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTYMK Protein Structure

Thymidylate_kin

0
100
200
212 a.a.

Protein Preferred Names	Protein Names
thymidylate kinase	dTMP kinase

Recombinant DTYMK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70012	Thymidylate Protein, Human (HEK293, His)	P23919 (M1-K212)	≥ 95%, as determined by reducing SDS-PAGE.

DTYMK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83129	DTYMK Antibody (YA2874)	WB, IHC-P, IP	Human
HY-P83129A	DTYMK Antibody (YA2874)(PBS only)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Neurodegeneration, Childhood-Onset, With Progressive Microcephaly	CONPM
Developmental And Epileptic Encephalopathy 50	DEE50 Epileptic Encephalopathy, Early Infantile, 50 Eiee50 Developmental And Epileptic Encephalopathy, 50 Congenital Disorder Of Glycosylation, Type Iz, Formerly Cdg1z, Formerly Carbohydrate Deficient Glycoprotein Syndrome Type Iz Cdg Syndrome Type Iz Cdg-Iz Congenital Disorder Of Glycosylation Type 1z Early Infantile Epileptic Encephalopathy 50 Cdg1z Congenital Disorder Of Glycosylation 1z Encephalopathy, Epileptic, Early Infantile,, Type 50
Submandibular Adenitis	Submandibular Lymphadenitis
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Mitochondrial Dna Depletion Syndrome	Mtdna Depletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04043	DTYMK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18173	Dtymk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24647	Dtymk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DTYMK	VGNC	VGNC:28240
Mus musculus	DTYMK	MGD	MGI:108396
Felis catus	DTYMK	VGNC	VGNC:61652
Macaca mulatta	DTYMK	VGNC	VGNC:72008
Canis familiaris	DTYMK	VGNC	VGNC:59076
Rattus norvegicus	DTYMK	RGD	RGD:1309614
Others	DTYMK	NCBI